Saturday, May 14, 2022

Can Brain Activity Be Restored

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Features Of The Confusional State

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  • Acting lost or confused. This may include not being able to keep track of the correct place and time.
  • Severe problems with attention, memory, and other mental abilities.
  • Changes in level of responsiveness.
  • Restlessness.
  • Feeling very tired and sleeping during the day.
  • Believing things that arent true.
  • Seeing things that arent there.

Pig Brains Partially Revived Hours After Deathwhat It Means For People

In a feat sure to fire up ethical and philosophical debate, a new system has restored circulation and oxygen flow to a dead mammal brain.

Scientists have restored cellular function in 32 pig brains that had been dead for hours, opening up a new avenue in treating brain diseaseand shaking our definition of brain death to its core. Announced on Wednesday in the journal Nature, researchers at the Yale University School of Medicine devised a system roughly analogous to a dialysis machine, called BrainEx, that restores circulation and oxygen flow to a dead brain.

The researchers did not kill any animals for the purposes of the experiment; they acquired pig heads from a food processing plant near New Haven, Connecticut, after the pigs had already been killed for their meat. And technically, the pig brains remained deadby design, the treated brains did not show any signs of the organized electrical neural activity required for awareness or consciousness.

Clinically defined, this is not a living brain, says study coauthor Nenad Sestan, a neuroscientist at the Yale University School of Medicine.

The new system instead kept the brains in far better shape than brains left to decompose on their own, restoring functions such as the ability to take in glucose and oxygen for up to six hours at a time. Researchers say that the technique could give a major boost to studies of human health by providing a rich testbed for studying brain disorders and diseases.

Brain 101

Reversing Brain Death: Far

From gene editing to human head transplantation, the limits of medical science are being pushed further than ever. And now, researchers have turned their attention to another extraordinary mission: reversing brain death.

Though it sounds similar to the makings of fiction, scientists have received approval for the first ever trial that aims to restore neuronal activity in humans who have been declared brain dead.

The proof-of-concept study which forms a part of the Reanima Project is the brainchild of two life sciences companies: Bioquark, Inc., based in the United States, and Revita Life Sciences, based in India.

Due to begin later this year, the trial will recruit 20 individuals who have suffered brain death as a result of traumatic brain injury , but whose bodies are biologically alive as a result of cardiopulmonary and trophic support a model referred to as a living cadaver.

To participate in the trial, each subject must be aged between 15 and 65 years, be unwilling for organ donation, and have written consent from a legally acceptable representative.

Researchers including Bioquark CEO Ira Pastor will test a variety of techniques that previous studies have demonstrated to possess neuroregenerative properties, and these will be combined with devices that have been shown to stimulate the central nervous system of coma patients.

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What Happens During Cardiac Arrest

During cardiac arrest, unconsciousness will occur rapidly once the heart stops beating, typically within 20 seconds. Deprived of the oxygen and sugars it needs to function, the brain will be unable to deliver the electrical signals needed to sustain organ function, including breathing.

This can lead to a hypoxic-anoxic injury . Hypoxia;refers to a partial lack of oxygen, while anoxia indicates a total lack of oxygen. In general, the more complete the deprivation, the more severe the harm to the brain.

With cardiac arrest, the lack of circulation affects not just one part of the brain but everywhere in the brain where blood flows. An injury caused by apoxia is referred to as diffuse brain damage. Among the parts of the brain most vulnerable to injury is the temporal lobe where memories are stored.

Can Dead Brains Be Brought Back To Life First Human Study To Find Out

mind reading device can translate your brain activity scaled

Last month, a Philadelphia-based biotech company kicked off a clinical trial that pushes the envelope of what it means to be dead.

Armed with ethical approval from the IRB at the Anupam Hospital in India, Bioquark is recruiting 20 patients who have been clinically deemed brain dead from severe traumatic brain injury.

With an arsenal of cutting-edge, if mysterious, treatment techniques stem cells, bioactive molecules, brain and spinal cord stimulation the team hopes to revive parts of the patients basic brain functions, with the eventual holy grail goal of returning the ability to breathe on their own.

The anticipated deadline for measurable results? A short 15 days.

Let that sink in.

If your first reaction is incredulity, youre not alone. What is this, The Lazarus Effect, Frankenstein, The Walking Dead? Some sort of viral campaign for an upcoming horror flick?

Not quite. A horde of zombies may not be in our future, but Bioquarks goals are to cheat death. Heres what the stunningly ambitious ReAnima project plans to do.

The Tricky Business of Defining Death

We often think of death as flipping a switch: one minute youre there, the next minute its all lights go out.

Brain death, in contrast, is final. The diagnosis signals a complete and irreversible destruction of the brain, including the brain stem. Brain dead individuals arent comatose or in a vegetative state. They have no hope for spontaneous recovery. Theyre dead.

The Lazarus Toolkit


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Activating Neuroplasticity Through Repetition

In the past, scientists believed that the adult brain was static.This meant that, after a certain point in development, the brain could nolonger adapt to change.

Today, however, research shows that the brain is always in a flexible state, even in old age. This flexible state is called plasticity.

Research has also demonstrated that repetitive actions engage neuroplasticity and cause changes in the brain. Therefore, a key aspect in stroke recovery is massed practice: exercises with high repetition.

When you perform an action, your brain creates new neural pathways in response to your movement. These pathways make it easier for the brain to store and retrieve information. The more you practice that action, the more you reinforce those neural pathways, and the easier that activity becomes.

This explains why the first time a person tries to play a chord on the guitar, for instance, it feels slow and clunky. But by the hundredth time, it feels second-nature. Thats neuroplasticity in action.

Therefore, to learn how to speak again after a stroke, you will need to practice speech therapy exercises several times a day. The same principle applies if you want to improve your balance, and even your memory.

Whatever ability you want to improve, with enough practice,you will activate neuroplasticity and help your brain heal itself after stroke.Eventually, you should start to regain that function.

Facts About The Vegetative And Minimally Conscious States After Severe Brain Injury

Consciousness is an awareness of ones self and surroundings. Brain injury can cause disorders of consciousness . Some injuries are mild; they may cause minor changes in consciousness such as brief confusion. Severe injuries can cause permanent unconsciousness.

Of people with severe injuries, 60% to 80% survive. Many of those who survive are completely unconscious for some period. During this time, they arent aware of themselves or the world around them. A state of complete unconsciousness with no eye-opening is called coma. A state of complete unconsciousness with some eye-opening and periods of wakefulness and sleep is called the vegetative state . This refers to the vegetative functions of the brain which often return before return of consciousness. As people recover from severe brain injury, they usually go through several phases of recovery. Recovery through these phases can slow or stop.

  • Coma
  • No speech or other forms of communication
  • No purposeful movement

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Tests To Confirm Brain Death

Although rare, a few things can make it appear as though someone is brain dead.

These include drug overdoses and severe;hypothermia, where body temperature drops below 32C.

A number of tests are carried out to check for brain death, such as shining a torch into both eyes to see if they react to the light.

How Is A Damaged Brain Treated

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A traumatic brain injury needs emergency care that aims at

  • Making sure there is enough oxygen: Oxygen will be delivered through a face mask connected to an oxygen cylinder. You may be put on artificial respiration with the help of ventilators.
  • An adequate blood supply: A blood transfusion may be done.
  • Maintaining blood pressure with fluids and medications.
  • Preventing any further injury to the head or neck.

Doctors will focus on minimizing further loss due to inflammation, bleeding or reduced oxygen supply to the brain.

Hyperbaric oxygen therapy

The doctor may prescribe hyperbaric oxygen therapy to improve the lost cognitive functions/skills, such as reading or cooking, after the brain damage. Currently, HBOT is one of the most important therapies for TBI. It involves putting you in an oxygen-rich chamber that increases the blood oxygen levels ten times the normal level.

Noninvasive brain stimulation

Noninvasive brain stimulation without the introduction of any instruments through the skin. It is a painless procedure for the treatment of TBI. Studies have shown that it could improve depression and cognitive function after TBI.

There is something known as a stem cell that seems to be a promising option to regenerate damaged neurons in the brain. Stem cells are a special type of cells that can be trained to develop into any kind of cell, such as a neuron. However, research is ongoing to determine the efficacy and safety of the therapy.

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When Damaged The Adult Brain Repairs Itself By Going Back To The Beginning

University of California – San Diego
When adult brain cells are injured, they revert to an embryonic state, say researchers. In their newly adopted immature state, the cells become capable of re-growing new connections that, under the right conditions, can help to restore lost function.

When adult brain cells are injured, they revert to an embryonic state, according to new findings published in the April 15, 2020 issue of Nature by researchers at University of California San Diego School of Medicine, with colleagues elsewhere. The scientists report that in their newly adopted immature state, the cells become capable of re-growing new connections that, under the right conditions, can help to restore lost function.

Repairing damage to the brain and spinal cord may be medical science’s most daunting challenge. Until relatively recently, it seemed an impossible task. The new study lays out a “transcriptional roadmap of regeneration in the adult brain.”

“Using the incredible tools of modern neuroscience, molecular genetics, virology and computational power, we were able for the first time to identify how the entire set of genes in an adult brain cell resets itself in order to regenerate. This gives us fundamental insight into how, at a transcriptional level, regeneration happens,” said senior author Mark Tuszynski, MD, PhD, professor of neuroscience and director of the Translational Neuroscience Institute at UC San Diego School of Medicine.

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Scientists Are Giving Dead Brains New Life What Could Go Wrong

In experiments on pig organs, scientists at Yale made a discovery that could someday challenge our understanding of what it means to die.

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    A few years ago, a scientist named Nenad Sestan began throwing around an idea for an experiment so obviously insane, so wild and totally out there, as he put it to me recently, that at first he told almost no one about it: not his wife or kids, not his bosses in Yales neuroscience department, not the dean of the universitys medical school.

    Like everything Sestan studies, the idea centered on the mammalian brain. More specific, it centered on the tree-shaped neurons that govern speech, motor function and thought the cells, in short, that make us who we are. In the course of his research, Sestan, an expert in developmental neurobiology, regularly ordered slices of animal and human brain tissue from various brain banks, which shipped the specimens to Yale in coolers full of ice. Sometimes the tissue arrived within three or four hours of the donors death. Sometimes it took more than a day. Still, Sestan and his team were able to culture, or grow, active cells from that tissue tissue that was, for all practical purposes, entirely dead. In the right circumstances, they could actually keep the cells alive for several weeks at a stretch.

    Dont forget the Kanye, Daniele joked.

    Our soundtrack, Vrselja said with a grin.

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    Can Brain Functionality Be Restored After Stroke

    The human brain is one of the largest and most powerful body organs. It is the central organ of the human nervous system. It weighs around 1.4kgs and in terms of length it is around 15cm. Human brain is divided into two halves right and left hemisphere, each hemisphere controls the opposite side of the brain. The right hemisphere dominates the left side of the body it is responsible for emotions, creativity and non-verbal cues while left hemisphere dominates the right side and is responsible for creativity, special ability. There are so many factors that affect brain development and brain functionality among them is diseases like stroke

    Stroke occurs when the blood supply to the part of your brain is interrupted or reduced preventing brain tissue from getting oxygen and nutrients. As a result, the areas of your body they control are also affected. For example, if you have visual problems, the stroke will have damaged the area of your brain responsible for your vision. Cognitive impairment and memory loss following stroke diagnosis are common symptoms that significantly affect the survivors quality of life. However according to Dr Jill Bolter Taylor stroke complication can be reversed by understanding the different ways in which the brain works and what to do in order to trigger memory gain, you can take steps with activities therapy and rehabilitation to help recover your memory after stroke. There are ways in which you can improve memory loss after stroke:

    What Causes Brain Damage

    Can Dead Pigs

    Brain damage can be caused either by a traumatic brain injury or acquired brain injury . Brain injuries can cause rupture or blockage of the blood vessels. Depending on the impact of the injury, oxygen and nutrient supply get disrupted to a part or all of the brain. Nutrient and oxygen deprivation of the nerve cells for a prolonged period may lead to brain damage.

    TBI refers to brain injuries caused by an external force. They usually result from head injuries. Examples include

    • Violent blow or jolt to the head
    • Objects, such as a bullet or shattered piece of skull, that penetrate the brain

    ABI refers to the brain injury that is acquired during your life. This means the injury was not congenital or due to genetic causes. An acquired brain injury or ABI includes injuries due to an external force . They, however, also include injuries that do not involve an external force, such as a tumor, stroke or a reduced supply of oxygen to the brain.

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    Brain Death Is Different From Vegetative State

    The difference between brain death and a;vegetative state, which can happen after extensive brain damage, is that it’s possible to recover from a vegetative state, but brain death is permanent.

    Someone in a vegetative state still has a functioning brain stem, which means:

    • some form of consciousness may exist
    • breathing unaided is usually possible
    • there’s a slim chance of recovery because the brain stem’s core functions may be unaffected

    Someone in a vegetative state can show signs of being awake. For example, they may open their eyes but not respond to their surroundings.

    In rare cases, a;person in a vegetative state may show some sense of response that can be detected using a brain scan, but not be able to interact with their surroundings.

    Can You Heal A Damaged Brain

    No, you cannot heal a damaged brain. Medical treatments can just help to stop further damage and limit the functional loss from the damage. The healing process of the brain is not the same as the skin. When the skin gets damaged, such as due to minor skin wounds, it usually heals wells without leaving scars. Major wounds can heal with scarring. Skin healing is completed by replacing the damaged/lost cells with new ones. In the brain, the damaged cells are nerve cells known as neurons and neurons cannot regenerate. The damaged area gets necrosed and it is never; the same as it was before.

    When the brain gets injured, you are often left with disabilities that persist for the rest of your life. Rehabilitation can help in functional recovery, but structural abnormality is hard to correct with available treatments.

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    A new experiment has raised medical and ethical questions as serious as those surrounding human gene editing: A support system delivering artificial blood to pig brains prevented degradation of important neural functions, Yale researchers discovered.

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    For their experiment, Sestan and his colleagues obtained some 300 pig heads from an abattoir near Yales New Haven, Conn., campus, over nearly 10 years as they worked to optimize BrainEx the ex stands for ex vivo, or out of the living. Eventually the team connected 32 pig brains to the system a Rube Goldberg-esque blur of software, blenders, fluid holders, pumps, heaters, filters, and more, whose function was to mimic pulsating blood flow using a special artificial blood via the carotid artery four hours after the animals had been killed. They kept the brains connected for six hours and at normal temperatures, not cryogenic ones.

    Other brains were hooked up to BrainEx but did not get the perfusion solution, or were not hooked up at all. By comparison, the brains connected to BrainEx and perfused showed dramatic differences, Sestan said. Brain cells metabolized oxygen and glucose much like living cells. Neurons fired information-carrying electrical bursts called action potentials both spontaneously and in response to an electrical stimulus, as those in living brains do. Blood vessels dilated in response to drugs that cause that response in living brains. Glia, the brains immune cells, revved up a lifelike inflammatory response when provoked. Mitochondria, which supply energy to cells, were intact inside neurons, as was myelin, the fatty sheath that provides insulation to neurons so they can conduct electrical signals.

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