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Does Rosuvastatin Cause Memory Loss

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Side Effects Requiring Immediate Medical Attention

Do statins cause memory loss & cognitive deficits new study

Along with its needed effects, rosuvastatin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rosuvastatin:

More common

  • muscle pain, cramps, spasms, or stiffness

Less common

  • chest pain, discomfort, tightness, or heaviness
  • difficult, burning, or painful urination
  • dry mouth
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • light-colored stools
  • muscle tenderness, wasting, or weakness
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pinpoint red spots on the skin
  • redness of the skin
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • upper right abdominal or stomach pain
  • vomiting of blood
  • yellow eyes or skin

Do Statins Cause Memory Loss

In February of 2012, the Food and Drug Administration told makers of cholesterol-lowering statinsa relatively safe drug class that has saved thousands of lives over the past two decadesto add new side effect warnings to their labels. According to the FDA, statin labels must now include the drugs known association with muscle injury and increased risk of diabetes. Garnering the most attention however is the drugs association with memory loss.

Beatrice Golomb is a medical researcher at the University of California-San Diego and a major advocate of statin use and memory loss. Recently, Golomb published a paper on 171 patients using statins who reported memory problems and dementia-like symptoms. The patients attributed their symptoms to their use of the statin medications. In her paper, Golomb shows that the vast majority of the patients symptoms improved upon stopping the drug and many saw symptoms return upon resuming usage.

Looking at the results from a different perspective, around 7% of the patients in the JUPITER trial reported neurologic and psychiatric side effects while taking Crestor. That means that for every person whose confused state was caused by Crestor, another 43 had neurological or psychiatric side effects not likely attributed to the drug. The combined data tends to support the hypothesis that Crestor-induced memory loss is a rare event.

It’s Not Dementia It’s Your Heart Medication: Cholesterol Drugs And Memory

Why cholesterol drugs might affect memory

ONE DAY IN 1999, Duane Graveline, then a 68-year-old former NASA astronaut, returned home from his morning walk in Merritt Island, Fla., and could not remember where he was. His wife stepped outside, and he greeted her as a stranger. When Gravelines memory returned some six hours later in the hospital, he racked his brain to figure out what might have caused this terrifying bout of amnesia. Only one thing came to mind: he had recently started taking the statin drug Lipitor.

Cholesterol-lowering statins such as Lipitor, Crestor and Zocor are the most widely prescribed medications in the world, and they are credited with saving the lives of many heart disease patients. But recently a small number of users have voiced concerns that the drugs elicit unexpected cognitive side effects, such as memory loss, fuzzy thinking and learning difficulties. Hundreds of people have registered complaints with MedWatch, the U.S. Food and Drug Administrations adverse drug reaction database, but few studies have been done and the results are inconclusive. Nevertheless, many experts are starting to believe that a small percentage of the population is at risk, and they are calling for increased public awareness of the possible cognitive side effects of statinssymptoms that may be misdiagnosed as dementia in the aging patients who take them.

doi:10.1038/scientificamericanmind0910-14

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Statins And Brain Fog

While statins have a lot of health benefits and are safe for most people to use, there are some side effects. These can include:

Brain fog is âa general level of confusion and disorientation,â says Robert Rosenson, MD, director of the Cardiometabolic Unit at Mount Sinai Hospital in New York City.

The FDA approved label changes for statins that list memory loss and confusion as a ânon-serious and reversible side-effect.â

Cholesterol is an important part of your brain. In fact, 25% of the bodyâs cholesterol is found there. So it may seem like statins could affect how your brain works.

But experts donât think thereâs cause for concern. Several studies on the drugâs side effects suggest thereâs no direct link. And the symptoms could be a sign of other problems, Rosenson says.

âThey forget where they put their keys down, they may open the refrigerator, put the keys in there, they forget and canât find them. But these are often signs of Alzheimerâs. And Alzheimerâs is a disease that develops over a long term,â he says.

These types of memory issues usually happen to people who are middle-age or older and can be a sign of many conditions.

âOne might need to ask the question: âIs it really the drug?â Or is there something else going on here that would require formal evaluation with a neuropsychiatric specialist,â Rosenson says.

Interactions Among Telmisartan Rosuvastatin And Apoe 4 Allele

Does Lipitor Cause Memory Loss

The declining trends in MMSE, MoCA, and DRS and the increasing trends in CDR and IQCODE were the lowest in the combination * 4 group and the highest in the control * 4 group after the patients were grouped based on telmisartan, rosuvastatin, and APOE 4 genotype. There were significant differences in the changing trends among these groups . Considering the changes in MMSE, MoCA, DRS, CDR, and IQCODE scores from the baseline, we did not find significant differences between the rosuvastatin * 4 and rosuvastatin * 4 groups and between the combination * 4 and combination * 4 groups . The cumulative hazards of the incidences of dementia were the lowest in the combination * 4 group and the highest in the control * 4 group . There were interactions among telmisartan, rosuvastatin, and APOE 4 genotype on the changing trends in MMSE , MoCA , DRS , CDR , and IQCODE and in the incidences of dementia after adjustment for confounders.

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Memory Loss Cause # 7 Thyroid Problems

According to recent clinical research studies, hypothyroidism is present in concerning 5% of individuals over the age of 65, as well as women are almost three times as most likely to have thyroid concerns. Hyperthyroidism is equally as hazardous, both to sleep and also overall wellness, and also study shows that 15% of people identified with an over active thyroid more than the age of 65.

Little is understood concerning exactly how exactly thyroid disorders affect memory, however research shows a clear link in between memory loss and also hypo as well as hyperthyroidism. Talk to your physician to locate out more concerning your thyroid wellness and also if there is anything you can do to aid improve your memory.

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The Negative Effects Of Statins On The Brain

02/04/2019 / By Tracey Watson

Statin drugs, prescribed by doctors to reduce high cholesterol levels and supposedly prevent heart attacks and strokes, are the second most prescribed drugs in the world, after the painkiller hydrocodone. Since one in five Americans between the ages of 40 and 75 take these drugs regularly, it is likely that you are acquainted with at least one person who is doing so.

Nonetheless, even though doctors hand out statins like candy, several studies have confirmed that they carry serious side effects. And the vast majority of patients are blissfully unaware of just how dangerous and indeed, ineffective they are.

One of the greatest concerns raised by experts is the potential for statins to cause damage to the brain, triggering memory loss and dementia.

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Waiting For More Research

While we wait for the proverbial more studies, what should doctors and patients do about the possibility that statins might sometimes produce memory deficits?

First, keep in mind that even if it turns out that statins can really cause this problem, the incidence appears to be quite low, and apparently the problem is said to be reversible. That is, it seems to go away if statins are stopped.

Second, if you or a loved one are taking a statin and notice some change in cognitive ability, bring it to the attention of your doctor right away. And remind them that there is indeed at least a possibility that the statin may be the culprit.

Finally, dont stop taking your statins without talking to your doctor.

Statin Benefits In Preventing And Treating Dementia And Alzheimers Evidence For

Atorvastatin and Dementia: Do atorvastatin and other statins cause dementia and memory loss?

Statins for the prevention and treatment of dementia began generating attention when two epidemiologic studies reported a lower risk of dementia in statin users . Since then, many medical professionals have investigated the potential beneficial effects of statins on long-term cognition and decreased incidence of cognitive related disease.

The protective effects of statins have been examined in a variety of reviews and meta-analysis . A meta-analysis that included observational studies and a randomized control study found a significant protective effect against all-cause dementia and Alzheimers disease with statin users . When compared to non-statin users, those who used statins had a significantly lower relative risk of developing all-type dementia .

Statin use was associated with significantly reduced risk of incident Alzheimers disease after adjustment for age, gender, education, and APOE genotype. A significant, but lesser, protective effect was found with non-statin lipid lowering agents conferring that the protective effect from statins may be due to their lipid lowering effects instead of potentially other novel mechanisms . However, most studies in the literature have found no association between non-statin lipid-lowering drugs and the risk of dementia .

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Statins And Memory Loss: Is There Reason To Worry

Approximately one in six adults in the United States has high cholesterol, a risk factor for chronic conditions like heart disease and diabetes, according to the Centers for Disease Control and Prevention. For millions of people, doctors prescribe statins, including such popular brand names as Lipitor, Zocor and Crestor, among others, to lower LDL or âbadâ cholesterol.

After some anecdotal reports that statin users experienced short-term memory lapses, the U.S. Food and Drug Administration issued warnings in 2012 that these medications may increase risk of memory loss. But now a new study suggests those warnings may be unfounded.

Researchers at Rutgers and the University of Pennsylvania looked at 482,542 new statin users and compared them to an equal number of people who were not taking any cholesterol-lowering drugs. Additionally, new statin users were also compared to another 26,484 people taking nonstatin lipid-lowering drugs .

The results, published today in The Journal of the American Medical Association-Internal Medicine, showed that more patients taking statins did indeed report short-term memory loss in the 30-day period after first taking the drug when compared to people not taking any cholesterol-lowering drugs. However, the same was true for patients taking nonstatin LLDs.

Stromâs conclusion then was that statins do not cause memory loss, but people are more likely to recognize health problems when they start a new drug â a so-called âdetection bias.â

Evidence For Statins Decreasing Risk Of Dementia

Statins are among the most frequently prescribed medications in the United States. Nearly one in three US adults age 40 and older is prescribed a statin. The benefits linked with these medications are very important in fighting cardiovascular disease, which remains our leading cause of death. Statins lower low-density lipoprotein cholesterol and triglycerides. They increase high density lipoprotein cholesterol, also known as the good cholesterol. Statins have been convincingly shown to reduce the risk of atherosclerotic heart disease and ischemic stroke.1

Thats great news, but what about the reports of cognitive problems linked with statin use?

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Do Statins Increase Or Decrease The Risk For Dementia

Christopher Labos, MD, CM, MSc

The other day I was emailed a link by a long-time statin user, concerned about reports that statins increase the risk for dementia. Unfortunately, stories that statins can cause dementia or memory loss have been with us almost since the drugs were first put on the market. In fact, worries that cholesterol-lowering medication could affect brain function predate statins by decades and seem to reappear with minor modifications every few years or so. But the real reason why such reports should not cause undue worry is that they rely on something that has led many researchers down blind alleys over the years: surrogate endpoints.

Interestingly, the worry that cholesterol might affect neurocognitive function dates back to one of the earliest cholesterol trials, the Coronary Primary Prevention Trial, which tested cholestyramine vs placebo. While the drug was associated with reduced cardiovascular events, there was also an increased risk for violent death by suicide, accident, or homicide. Some worried that statins were reducing cholesterol levels to such a degree that there was insufficient cholesterol left for brain cells to function normally, leading to increased rates of depression or altered behavior, and therefore suicide or accidental death. Why this would make one more prone to death by homicide was never entirely clear.

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Tables

Standard Protocol Approval Registration And Patient Consent

Ankh Rah

This study was conducted in compliance with the Declaration of Helsinki and adhered to good clinical practice guidelines. The study protocol was approved by the Research Ethics Committee of the Institute of Basic Medicine, Shandong Academy of Medical Sciences, and was retrospectively registered with ChiCTR.org.cn . Written informed consents were obtained from all the patients.

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Statins And Cognitive Function

Cholesterol is vitally important for brain function. While the brain represents 23% of total body weight, 25% of the cholesterol in the body is found in the brain, where it plays important roles in membrane function. Because cholesterol synthesis is essential for the normal functioning of the brain, it is theoretically possible that excessive inhibition of cholesterol synthetic pathways may result in neurocognitive adverse effects. Statins may reduce cholesterol synthesis in the brain and interfere with myelin formation and function. In a mouse model, simvastatin impaired remyelination after chemical demyelination . Alternatively, statins induced reduction in coenzyme-Q10 levels and may lead to impaired mitochondrial functioning and increased oxidative stress, which may have an adverse effect on cognition.

Statins may affect cognition through their effect on the level of cholesterol. Alternatively, statins may exert pleiotropic effects unrelated to their effect on cholesterol. Several preclinical studies using cell cultures and animal models of AD have demonstrated that statins increase -secretase activity and decrease A production . In humans, lovastatin decreased serum A levels in a dose-dependent manner when given to subjects without dementia .

In a study looking at brain autopsies from 110 subjects, ages 6579 years, neuropathologic findings were compared between statin users and nonusers. The risk for typical AD pathology was reduced in statin users .

Cholesterol Levels And Dementia Risk

An observational study is one that looks at large numbers of people over time and tries to find patterns and relationships between different factors . These studies can be very helpful for our understanding of things that change the risk of certain conditions, and they have been very helpful in finding things that may affect the risk of developing dementia.

Observational studies analysing a link between high cholesterol levels and development of dementia have mixed findings. A review that looked at 25 of these studies suggests that higher cholesterol in mid-life is associated with an increased risk of developing the condition.

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Side Effects Not Requiring Immediate Medical Attention

Some side effects of rosuvastatin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • tender, swollen glands in the neck
  • voice changes
  • accumulation of pus, swollen, red, or tender area of infection near a tooth
  • arm, back, or jaw pain
  • burning feeling in the chest or stomach
  • burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  • excess air or gas in the stomach or bowels
  • excessive muscle tone
  • feeling of constant movement of self or surroundings
  • feeling of warmth or heat
  • feeling sad or empty
  • flushing or redness of the skin, especially on the face and neck
  • general feeling of discomfort or illness
  • lack or loss of strength
  • lightheadedness
  • pain or swelling in the arms or legs without any injury
  • pain or tenderness around the eyes and cheekbones
  • passing gas
  • stomach discomfort, tenderness, or upset
  • stuffy nose
  • swelling of the breasts or breast soreness in both females and males
  • unsteadiness or awkwardness

Applies to rosuvastatin: oral capsule, oral tablet

The Link Between Increased Statin Use And The Dementia Epidemic

Statins and Memory Loss? Forget About It

As noted by the organization Be Brain Fit , there has been a massive increase in the number of Americans taking statin drugs like Crestor and Lipitor in recent years. At the same time, there has been an astronomical increase in the number of people experiencing memory loss, dementia and Alzheimers disease, which is now the sixth leading cause of death in the United States. BBF suggests that these two statistics may be no coincidence.

People are generally only told about the link between cholesterol and heart disease, but cholesterol also has incredibly important functions in the body. It is found in particularly high concentrations in the brain, with more than 60 percent of this important organ consisting of fat. The brain uses cholesterol to manufacture neurotransmitters, the chemicals which enable brain cells to communicate with each other. Neurotransmitters are also responsible for regulating mood, as well as facilitating focus and the ability to remember things, learn new things and cope with stress.

When normal neurotransmitter activity is disrupted, psychiatric disorders and nervous system diseases can be triggered.

For this reason, doctors admit that high cholesterol levels help prevent dementia in the elderly but will not admit the inverse: that low cholesterol levels can be linked to an increased risk of Alzheimers and other forms of dementia.

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