Cb1 Receptor Weight Loss Drugs
Not surprisingly, the pharmaceutical industry has already started exploring CB1 receptor drugs as potential weight loss weapons.
In 2006, a medication called rimonabant which acted as a selective CB1 antagonist/inverse agonist was approved in 30 countries for the treatment of obesity. However, severe psychiatric side effects, including dizziness, anxiety, depression, and nausea, caused medication to be withdrawn several years later.
Current studies suggest that peripherally restricted CB1 receptor antagonists may provide therapeutic benefits in obesity without the same psychiatric side effects.
As researchers note:
A therapeutic approach that acts both peripherally and centrally on the endocannabinoid system but does not cause severe psychiatric side effects is of great interest. Peripherally restricted CB1 receptor antagonists such as URB447 and AM6545 are showing promise
Weed For Weight Loss And Diabetes Management
Unfortunately, weed is not the answer when it comes to weight lossnot yet, at least. While these studies are certainly interesting, I would not recommend it for that purposeafter all, there are contradictory appetite stimulating and suppressing effects of the compounds in cannabis, says Chen. Even more troubling, cannabis can have the opposite desired effect in some cases. There have been studies showing a correlation between cannabis use and an increased risk of prediabetes, which is a state where blood sugar is abnormally high and often leads to developing diabetes.
Furthermore, Chen says, there are a few studies showing a correlation between using cannabis and having a heart attack in the timeframe immediately after cannabis use. This is especially dangerous for individuals who are obese or diabetic and are at a higher risk for cardiovascular disease and heart attack.
Most medical experts have similar conclusions when discussing cannabis: There appears to be some promise, but we need more research. Chen stresses that while these studies dont do much to prove that marijuana is the key to weight loss and diabetes treatment, they inspire more researchand thats a good thing. In one study, type-2 diabetics who were treated with the cannabinoid THCV were found to have lower blood sugar and improved pancreatic function. Now researchers and pharmaceutical companies are further investigating whether this cannabinoid can aid in weight loss and treat diabetes.
How To Grow New Brain Cells
This is where things get good. In a TED Talk, Doctor Sandrine Thuret, a neuroscientist at Kings College London, explains that until the 1990s people thought that adults couldnt generate new brain cells. But now we know that they do.
Here, then, are 10 ways to grow new brain cells:
As you can see from the list above, there are lots of simple things you can do to grown new brain cells. Once youve grown new brain cells, you need to maintain them. Youll discover how in the next section of this blog post.
It Can Interrupt Your Brain’s Reward System
“Daily cannabis use can disrupt reward circuity, making cannabis use even more desirable to users,”Dr. Aimee Chiligiris, PsyD, a psychologist at Smithers Center at Columbia Doctors Midtown, tells Bustle. “This may interrupt other previous seeking of pleasurable experiences, such as relationships, hobbies, and academics.”
Are Changes In The Brain From Drug Use Reversible
Certain brain changes can be persistent or permanent, but this can vary widely depending on the type of injury and the substance of abuse. Many substance-related neurological complications or consequences may also be reversible.
WKS, for instance, may present with more chronic and debilitating effects, but when caught early and with proper treatment, WKS might be reversible in certain cases. Research has shown that even people who have suffered from a stroke can make some degree of recovery. Studies have also shown that brain shrinkage and reduced white matter volume associated with alcohol abuse may be reversible.24,25,26,27
NIDA explains that some of the neurological damage to the dopaminergic system appear, at least partly, to be reversible, with many neurological markers for nerve damage returning to normal after several months of abstinence.28 The National Institute on Alcohol Abuse points out that although it can take time, most people suffering from alcohol addiction will experience at least some improvement in brain structure and functioning with abstinence.3
Simple Ways To Keep Your Brain Sharp Healthy
From a glance at the magazine stands, Americans appear obsessed with losing weight, cutting their cardiac risks and seeking to improve their odds against cancer. But wheres the focus on brain health?
The brain always has been mysterious and many people seem to believe little can be done to keep it sharp or to reduce its risk of injury and disease. Too many of us think its a matter of our genes or happenstance as to what occurs with memory loss, brain tumors, strokes and other disorders of the brain.
This may be true to some extent but the same might also be said of heart ills and many cancers. And while there may be familial predispositions, this doesnt diminish the need to take steps to improve health and reduce risk.
Keith L. Black, M.D., chairman of the Department of Neurosurgery at Cedars-Sinai Medical Center and director of the Maxine Dunitz Neurosurgical Institute, says Americans can do more to keep their minds sharp and brains healthy even as they age. His suggestions include: the simple and obvious ; the simple and less obvious ; and the simple and more obscure .
The theme is simple these are changes most people can work into their everyday lives. Examples include:
Eat a nutrient-rich diet. Deficiencies in certain vitamins have been shown to decrease memory skills. B vitamins appear to be key for concentration and memory.
If tired, nap and try to get to bed earlier. Sleep deprivation affects the brains ability to store and recall memories.
In One Study Marijuana Killed Brain Cells That Were Cancerous
While brain cancer is relatively rare, the thought alone is terrifying to many people. Luckily for people who consume cannabis, research from a team of Spanish scientists has shown that THC may shrink braintumors.
The study, which was conducted by Guillermo Velasco and his Complutense University colleagues, used mice inflicted with human tumors as study subjects. The researchers found that when the mice were administered with THC, the size of their tumors shrank significantly.The study also included two human subjects with an aggressive type of brain cancer. After a 26- and 30-day treatment with THC, researchers found that THC was actually able to eliminate these subjects’ cancer cells while leaving healthy brain tissue intact-so it seems that in some cases, marijuana does kill brain cells.
While more research is needed to fully solidify the anti-cancer properties of marijuana, it’s clear that cannabis may one day become a primary go-to for healthy, non-toxic brain cancer treatment.
When Use Becomes Abuse And Then Addiction
As more research is conducted, it is becoming clearer that the younger a person begins regularly smoking weed, the more likely they are to develop a marijuana use disorder. One study indicates that kids ages 12-18 who smoke regularly maybe 4-7 times more likely to have a marijuana use problem that continues into adulthood.
A common belief is that marijuana is not and cannot be addictive, but studies are showing that large amounts of marijuana used on a daily or near-daily basis can result in addiction, and this addiction can ruin lives.
Get Your Medical Marijuana Card
To find out if youre eligible for medical marijuana treatment and/or to receive your cannabis certification for overweight or obesity, please call 420-9170. You can also fill out a quick and easy online form!
If youd like to learn more about medical marijuana for weight loss and other conditions, please download our FREE e-book. CannaMD has a statewide team of experienced medical marijuana doctors who are available to answer any questions you might have!
Can You Get Help And Treatment For Marijuana Addiction
Currently, you can get treatment for marijuana addiction or a marijuana use disorder. It may not be common but there are those who seek and benefit from treatment for it. Treatment options right now are most often centered around things like binge use. Binge use is when you are using a lot of a substance, especially in a short period of time.
Treatment also focuses on things like withdrawal. Studies show that withdrawal from marijuana is possible and it can lead to an increase in the side effects and symptoms we listed above. Aside from these two main pieces, the treatment also often tries to help with the feelings of preoccupation with using.
Part of addiction is the intense need or craving to use a substance. Addiction to marijuana is no different and some of that impacts the effectiveness of treatment and the potential for relapse. This means it is critical that care focuses on that as well.
Less common is the potential of pharmacological treatments for it. This would be treatments for marijuana use disorder that rely on medications to be effective. For other drugs of use like opioids, this type of treatment has been thoroughly proven as safe and effective. It is called medication-assisted treatment and has been around for a long time. For marijuana, however, it is not used and studies are still being conducted to determine the safety and effectiveness of it.
Studies With Young Adults
Almost five thousand young adults in a coronary artery risk development study were tracked over 25 years until mid-adulthood. The researchers found that lifelong marijuana use appeared to have a cumulative effect and was associated with reduced scores on a verbal memory test.
THC appears to have no direct effect on cognitive abilities like processing speed. That was a significant finding that persisted even after adjusting for demographics, other substance use, and mental health issues.
Two longitudinal twin studies found that young twins who used marijuana showed a significant loss of verbal ability equivalent to four IQ points.
The twins also displayed overall deficits in general knowledge. Cognitive deficiencies were observed during the preteen years, late adolescent years, and in early adulthood.
A shorter-term twin study found no significant differences between twins when one twin used marijuana and the other twin did not.
Effect Of Marijuana Use On Iq
The effect Marijuana has on the brain is influenced by the amount a person has smoked and the users age. Individuals under 25, whose brains are still developing, are most susceptible to the effects of Marijuana on the brain. A study of Marijuanas effect on IQ revealed individuals who began using Marijuana at a young age lost 6 to 8 points from their IQ by middle age. Moreover, those who smoked Marijuana throughout their adolescence, then stopped, did not regain their IQ points. Conversely, individuals who began using Marijuana in their adulthood did not experience any IQ loss.
Marijuanas Effects On The Brain
Studies have almost universally concluded that adults using Marijuana in moderation will most likely not see serious negative consequences. The most serious negative health consequences associated with regular Marijuana use depend more on the method of ingestion. Smoking and vaping both create issues in the lungs, but dont seem to produce cognitive issues. The results for adolescents are not quite as clear. Several studies based around adolescent Marijuana use have found that taking Marijuana in large amounts regularly could be correlated to mental consequences later in life.
How Marijuana Interferes With The Brain
Experts do not believe that marijuana use damages or destroys brain cells. However, marijuana effects on the brain can be many, including the inhibition of short-term memories, distorting the perception of time, and regulating appetite. THC, the psychoactive ingredient found in marijuana, interferes with cannabinoid receptors in the brain.
After a user ingests marijuana, its chemicals make their way into the bloodstream, which carries these different substances throughout the body. Also, cannabis contains molecules that are similar to those produced in the brain, known as cannabinoids. Once THC reaches the brain, it binds to these receptors, which are then directly affected by the chemical.
Marijuana Weight Loss Theory
Scientists with Cannabis and Cannabinoid Research have proposed a novel theory that cannabis use reverses the impact of the standard American diet by reducing the effects of an elevated ratio of omega-6/omega-3 fatty acids on endocannabinoid tone.
The idea goes something like this:
1. The standard American diet contains a lot of sugars and refined starches that result in an elevated omega-6/omega-3 ratio.
2. Omega-6 fatty acids are converted into cannabinoids called AEA and 2-AG, which stimulate CB1 receptors. CB1 receptors play a huge role in regulating appetite and metabolism.
3. An elevated omega-6/omega-3 ratio results in more AEA and 2-AG, which leads to overstimulation of CB1 receptors and increased appetite and metabolism dysfunction.
4. Cannabis, and specifically THC, down-regulates CB1 activity. Although marijuana causes an initial up-regulation , it quickly switches to influence longer lasting down-regulation behavior.
But why is THC so important?
Unlike other phytocannabinoids , THC is able to bind directly with CB1 receptors making it the main cannabinoid that can get the job done.
The proposed theory solves a lot of problems with previous research, as the study authors explain:
This logic also addresses the question of how medical marijuana and cannabis-based drugs like Marinol can increase appetite and weight gain in patients suffering from condition or treatment-related anorexia or wasting, but still increase weight loss in other patients.
Hypoxic Brain Damage From Overdose
Overdoses of certain substances can lead to potentially fatal neurological complications and injuries, including hypoxia, the shortage of oxygen delivery to the brain, and anoxia, meaning the total loss of oxygen that is usually due to hypoxia.17,18
Hypoxic brain injury can occur due to respiratory depression, a serious consequence of opioid overdose.19 In addition to being a particular risk with opioids , use of benzodiazepines, alcohol, or other sedatives can also lead to respiratory depression. Poly-substance use, which often involve combining substances that have depressant effects, such as opioids, sedatives, or alcohol. Combining substances in generalbut especially depressantscan have unpredictable and dangerous outcomes.19
Overdose survivors may develop a hypoxic brain injury that leads to long-lasting or even permanent damage such as short-term memory loss, stroke, mental disorientation, loss of body movement, changes in gait, incontinence, temporary leg paralysis, reduced motor skills, slowed reaction time, seizures, nerve injury, and memory impairment.20
Long Term Effects Of Cocaine Use On The Brain
If you use cocaine for a long period of time your brain might have long-term effects which can include:
- Severe depression
- Increased risk for disorders like Parkinsons disease, schizophrenia, and bipolar disorder
- Delirium or psychosis
- Seizures and other neurological conditions
- Permanent damage to blood vessels
- Cognitive decline which may lead to disorientation and mental confusion
All About Marijuana And Brain Health: The Good And The Bad
Lets start by covering the basics. Most of us know by now that marijuana is a plant that occurs naturally. It is actually a plant known as cannabis. As is the case with most plants, cannabis can come in a couple of different types. The two main types of cannabis are Cannabis sativa and Cannabis sativa L.
Cannabis sativa L is the non-psychotropic, or non-mind altering, type. It is most commonly used in the materials industry. It can be used to produce oils, materials for clothes, rope, and much more. Its commonly referred to as hemp. More now than ever before, it can also be found within a variety of beauty products like lotions and shampoos. Some crafting kits even boast the inclusion of hemp string for friendship bracelets.
Part of this major uptick in the use of hemp is due to its small environmental impact compared to most synthetic materials. This actually is part of what draws people to using marijuana as well for things like anxiety or pain instead of pharmaceutical options.
Marijuana And The Brain
The thing that makes substances of use, like illegal drugs, misused medications or alcohol so unique is that they change or alter the usual mechanics of the brain. They do this because they are made up of special chemicals that change the way the current chemical cycles in the brain work. THC and the other components of marijuana are what directly impact the brain and can even change its chemistry.
In our brain, we have special messenger chemicals called neurotransmitters. These messenger chemicals are responsible for signals moving through the brain and most of the rest of the body. They are responsible for emotions like happiness or sadness and even reactions like when you accidentally touch a hot plate.
There are a ton of different types of these neurotransmittersor messengersin the brain. Each of them has different functions and specialties. You can think of them as a mail system.
Some mail trucks come by every day with our standard packages and envelopes but sometimes we ordered items like a new TV or maybe even a new mattress online. When those packages get sent out they dont fit in the everyday USPS truck, and they come in via a bigger box truck and get dropped off at a different time, or maybe even right at your front door rather than the mailbox down the driveway.
What Can You Do About Marijuana Dependence
Though marijuana can create a distorted sense of euphoria when consumed, this temporary state is not worth the adverse effects it entails. When abused, marijuana can become very harmful.
Stopping marijuana use may be a difficult challenge, but it is not impossible. By undergoing proper treatment and counseling, you or your loved one can live a healthier life.
Marijuana, synthetic marijuana, and their variants contain chemical compounds, THC and cannabinoids, that affect specific brain receptors. These receptors are attached to nerves that govern several body functions.
When abused, marijuana can cause negatively affect the brain, causing a lot of adverse effects in both the short-term and long-term. Constant usage of marijuana can promote both brain and body deterioration.
If you or someone you know is struggling with addiction, dont hesitate to seek help. Visit Roots Through Recovery addiction treatment center in Long Beach, CA located at 3939 Atlantic Ave, Suite 102 Long Beach, CA 90807 or call .
Evidence Suggests That Marijuana Doesn’t Kill Brain Cells
While opponents of cannabis are quick to point out that marijuana damages the brain, many studies are now debunking the myth that marijuana kills brain cells. In fact, the cannabinoids found within marijuana may actually help rebuild them. From assisting in neurogenesis to protecting against cognitive decline and chronic stress, marijuana is a complex compound that offers a whole host of well-noted benefits.
Photo Credit: Michael
The Harmful Effects Of Marijuana
The immediate effects of taking marijuana include rapid heart beat, disorientation, lack of physical coordination, often followed by depression or sleepiness. Some users suffer panic attacks or anxiety.
But the problem does not end there. According to scientific studies, the active ingredient in cannabis, THC, remains in the body for weeks or even months.
Marijuana smoke contains 50% to 70% more cancer-causing substances than tobacco smoke. One major research study reported that a single cannabis joint could cause as much damage to the lungs as up to five regular cigarettes smoked one after another. Long-time joint smokers often suffer from bronchitis, an inflammation of the respiratory tract.
The drug can affect more than your physical health. Studies in Australia in 2008 linked years of heavy marijuana use to brain abnormalities. This is backed up by earlier research on the long-term effects of marijuana, which indicate changes in the brain similar to those caused by long-term abuse of other major drugs. And a number of studies have shown a connection between continued marijuana use and psychosis.
Marijuana can change the structure of sperm cells, deforming them.
Thus even small amounts of marijuana can cause temporary sterility in men. Marijuana use can also disrupt a womans menstrual cycle.
Studies show that the mental functions of people who have smoked a lot of marijuana tend to be diminished. The THC in cannabis disrupts nerve cells in the brain, affecting memory.
It Can Increase Your Risk Of Psychosis
Marijuana use can cause or exacerbate symptoms of psychosis, which may include paranoia or hallucinations, according to Dr. Chiligiris. “Individuals with certain genetic vulnerabilities may be at greater risk to developing psychosis with cannabis use,” says Dr. Chiligiris. “With higher potency THC available, including edibles, individuals may be at risk for more significant or earlier onset of mental health concerns such as psychosis.” While this may not be the case for everyone, it is something to consider.
Signs Of Marijuana Addiction
Perhaps you are reading this because you Googled does smoking weed really kill brain cells, because you are worried about your marijuana use and how it is affecting your life, but are still not sure if you have a problem. If you suffer any of these signs of addiction, its time to seek help:
- Inability to quit using
Final Thoughts On Weed & Brain Cells
Not only is the weed kills brain cells theory a complete myth, but it is also the sheer opposite of reality! In certain circumstances, marijuana helps brain function, and while we are wary about adolescents using it, dozens of studies have determined that cannabis causes no long-term brain damage in adults, or drop in memory, ability to learn, etc.
Nonetheless, marijuana is still Public Enemy Number One in the eyes of some. Meanwhile, we continue to ply ourselves with alcohol even though it is proven to have a negative impact on our brain cells. A 2017 study by Thayer et al. for example, found that while chronic alcohol use was associated with lower gray matter volume and white matter integrity, the same could not be said for marijuana.
It seems that no matter how much data we have that proves marijuana doesnt kill brain cells, anti-marijuana lobbyists will always twist the information to meet their agenda, just like the infamous New Zealand IQ study.
What About The Munchies
Before exploring theory details, one important point deserves attention:
Marijuana users eat more than non-marijuana users .
Almost every study cited above highlights increased caloric intake among marijuana users. One group of researchers found:
sers who had consumed cannabis for more than 1,800 days over 15 years consumed on average 619 more calories/day than nonusers, yet showed no difference in BMI.
Likewise, in a study of 10,623 U.S. adults aged 29-50, Public Health Nutrition reports:
We found caloric intake to be higher among marijuana users than among non-current users and that the intake increased as frequency of marijuana use increased.
Although energy intake was higher among marijuana users, their body mass index was somewhat lower.
Across these studies, on average, cannabis users consumed an additional 834calories/day relative to nonusers.
As the BMI of cannabis users is lower than non-users, this suggests that marijuana users must have increased metabolic rates which brings us to the next piece of our puzzle.
The Mailing System Of The Brain And Thc
Think of the receptor system in the brain like that mail system that we discussed before. Once they drop off their package at the mailbox, then the package spends time in the mailbox or at the door. This is similar to how a chemical transfer works in the brain. Once the neurotransmitter drops the chemical off, then the chemical gets to work producing the feeling associated with the message, whether the message they are sending and receiving is about happy feelings or more negative feelings.
So for example, lets say that the dopamine mailman has come and delivered your daily dose of dopamine. Once the dopamine has linked up to your receiving mailbox, then it sits there and does its business to make us feel happy. After a time, we goes to pick up the mail for the day and disconnects that dopamine from the receptor in the mailbox.
This allows the receptor to be ready to accept its next drop off from the mailman. The same can be said for the cannabinoid receptor system that THC impacts. Once the cannabinoids have linked up with their special receptors, a protein comes along and removes the messenger chemical from the receptor.
When using drugs or alcohol, this communication or mailing process can get knocked out of sync or out of order. This can cause the neurotransmitter to stay connected to its receptor longer or to even potentially come back too soon.