Friday, May 13, 2022

How Do Mushrooms Affect Your Brain

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Your Brain On Shrooms

This is our secret sauce. But you can decide what you think for yourself. Microdosing magic mushrooms is transforming how depression and anxiety are treated. The thing is, after years of depression and years of taking pharmaceutical drugs people often struggle with other aspects of brain health, notably memory and focus and just feeling happier.

Lions mane can help with all of this.

Lions mane mushroom, a medicinal, totally legal mushroom native to North America, Europe and Asia, has been used for centuries in traditional Chinese medicine. When extracted, concentrated, and used in conjunction with magic mushrooms , this brain-boosting mushroom has benefits that amplify a magic mushroom-only microdosing regimen:

  • Enhances cognitive function

There is also evidence that suggests lions mane mushroom:

  • May be a natural remedy for depression and anxiety
  • Improves mental health, particularly for people who are at risk of dementia
  • Boosts immune health

What is so profound about lions mane mushroom is it permanently enhances cognition and encourages the brain to alter itself structurally.

What are the long term results of taking lions mane mushroom?:

  • Increased mental stamina to bust through your to-do list
  • Ability to intensely focus on your tasks
  • Enhanced problem-solving capabilities

Lions mane and magic mushrooms potentiate one another. This means that when taken together, they work to bring out each others best assets.

These Hallucinations May Be Key To Understanding How Shrooms Could Help Ease Depression

Imperial College London neuroscientist David Nutt, who authored a 2012 study on psilocybin, also found changes in the brain activity patterns of people on the drug. While some areas became more pronounced, others were muted including in a region of the brain thought to play a role in maintaining our sense of self.

In depressed people, Nutt believes, the connections between brain circuits in this sense-of-self region are too strong. “People who get into depressive thinking, their brains are overconnected,” Nutt told Psychology Today. But loosening those connections and creating new ones, the thinking goes, could provide intense relief.

Psychedelic Mushrooms Put Your Brain In A Waking Dream Study Finds

Psychedelic mushrooms can do more than make you see the world in kaleidoscope. Research suggests they may have permanent, positive effects on the human brain.

In fact, a mind-altering compound found in some 200 species of mushroom is already being explored as a potential treatment for depression and anxiety. People who consume these mushrooms, after “trips” that can be a bit scary and unpleasant, report feeling more optimistic, less self-centered, and even happier for months after the fact.

But why do these trips change the way people see the world? According to a study published today in Human Brain Mapping, the mushroom compounds could be unlocking brain states usually only experienced when we dream, changes in activity that could help unlock permanent shifts in perspective.

The study examined brain activity in those whod received injections of psilocybin, which gives “shrooms” their psychedelic punch. Despite a long history of mushroom use in spiritual practice, scientists have only recently begun to examine the brain activity of those using the compound, and this is the first study to attempt to relate the behavioral effects to biological changes.

Youre seeing these areas getting louder, and more active, he said. Its like someones turned up the volume there, in these regions that are considered part of an emotional system in the brain. When you look at a brain during dream sleep, you see the same hyperactive emotion centers.

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Here’s What Magic Mushrooms Do To Your Body And Brain

There’s evidence that tripping on magic mushrooms could actually free the mind. Several studies, including two promising recent clinical trials, suggest that psilocybin – shrooms’ psychoactive ingredient – may hold the potential to help relieve severe anxiety and depression.

Still, because they’re classified as Schedule 1 – meaning they have “no accepted medical use” and are illegal – it’s been pretty tough for scientists to tease out exactly what they can and can’t do.

Here are a few of the ways we know shrooms can affect your brain and body:

Shrooms can make you feel good.

According to the National Institute on Drug Abuse, magic mushrooms can lead to feelings of relaxation that are similar to the effects of low doses of marijuana.

Like other hallucinogenic drugs, such as LSD or peyote, shrooms are thought to produce most of their effects by acting on neural highways in the brain that use the neurotransmitter serotonin, according to the National Institute on Drug Abuse.

More specifically, magic mushrooms affect the brain’s prefrontal cortex, part of the brain that regulates abstract thinking, thought analysis, and plays a key role in mood and perception.

They can also make you hallucinate.

Journal of the Royal Society Interface

Above: Visualisation of the brain connections in a person on psilocybin and in someone given a placebo .

To visualise what they were seeing in the people given the drug , the researchers created the representation above.

Your pupils may also dilate.

The Neuroscience Behind The Mystical Experience

How Do Magic Mushrooms Affect My Brain?

Theres an ever-growing body of scientific research that shows psilocybin, the psychoactive compound in hallucinogenic mushrooms, can provide therapeutic benefits. From helping people recover from smoking addictions to reducing anxiety and depression in patients with chronic illnesses, the psychedelic drug has proven to have profound, transformative effects.

While tripping on mushrooms, people report intense hallucinations, distorted perceptions of reality, and intensified emotions. So, whats going on in the brain and body under the influence of psilocybin that brings about these fantastical effects?

1. Psilocybin gets broken down into psilocin

According to an AsapSCIENCE video, the first thing that happens after a person takes shrooms is that the psilocybin gets broken down into psilocin, an active chemical that makes its way to the brain.

2. Serotonin reuptake is prevented

Once psilocin reaches the brain, it prevents the reuptake of serotonin, the neurotransmitter that affects our mood, social behavior, memory, and sexual desire.

Interestingly, psilocin actually has a similar chemical structure to serotonin, which enables it to bind to and stimulate receptors in the brain. This amplified stimulation is what brings upon hallucinations the brain is led to perceive and experience things without any real stimulus.

3. Sense of time is warped

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How Do Psychedelics Affect The Brain

    Classic psychedelics like LSD and psilocybin are chemically similar to the neurotransmitter serotonin produced by the brain. Serotonin is involved in many neural functions including mood and perception. By mimicking this chemicals effects, the drugs exert their profound effects on subjective experience.

    DMT too acts via serotonergic pathways , but also through other routes for instance, DMT binds with sigma-1 receptors that are involved in the communication between neurons.

    Meanwhile, ketamine among many other effects blocks NMDA receptors that are involved in the functioning of the neurotransmitter glutamate.

    A key brain area for psychedelic drugs effects appears to be the temporal lobe, the location of much emotional and memory functioning. For instance, removal of the front part of the temporal lobe has been shown to prevent the psychological effects of taking LSD.

    Interestingly, abnormal activity in the temporal lobe, such as during seizures, can lead to events similar to near death experiences.

    An effect shared by different psychedelic substances is that they increase the amount of disorganised activity across the brain a state that neuroscientists describe as being higher in entropy.

    One consequence of this is a reduction in the activation of a group of brain structures known collectively as the default mode network, which is associated with self-conscious and self-focused thought.

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    How Are Shrooms Detected

    Shrooms can be detected by a variety of methods including lab tests. The time frame is dependent on the type of testing including urine, saliva, blood and hair. If you receive a positive result after your first test, you will be tested again for confirmation. The drug can be detected in your blood a maximum of 30 minutes after you use shrooms.

    The substance will stay in your blood for as long as 24 hours. Blood tests are rarely used for testing due to the short detection windows and invasiveness of the test. The most common test for shrooms is urine. The substance generally remains in your urine between 24 and 48 hours after your last dosage. If you consume shrooms on a regular basis, testing can detect the substance for as long as three days after your last dose.

    In most cases, shrooms will not show in your hair growth for approximately a week. The substance can be detected for as long as 90 days by testing your hair follicles. Psilocybin enters your system in very small amounts. This means more hair is required for a drug test than with any other substance.

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    How Microdosing Daily Discredits The Movement

    Microdosing magic mushrooms is more than about educating people about a natural treatment to improve mood. Its a movement. Its about reclaiming the bounty of medicine that is provided by nature and showing it is okay to question how the medical community and pharmaceutical industry prescribes treatment for mental health.

    When we follow microdosing regimens that allow for days off, we demonstrate that we value the power of this plant medicine and respect its strength. We show that we understand what is known about how psychedelics impact the brain based on the best and most current science available to us.

    Following microdosing regimens responsibly helps to break down the social stigmas and stereotypes about psychedelics. Did you know that Imperial College London, the first Centre for Psychedelic Research in the world, feels microdosing magic mushrooms could break Big Pharmas stronghold on the antidepressant market within 5 years? The market on antidepressants is predicted to be worth $15.9 billion by 2023.

    Thats a clue. Its also a momentum we want to keep going. To everyone who microdoses or sees its value, this shows you we truly have something special. We are onto something.

    Check out the Complete Beginners Guide To Microdosing Psilocybin Mushrooms HERE

    You can send us a confidential message using the secure contact form below. Please note that we do not sell any products containing psilocybin or offer sourcing referrals.

    Easy Steps To Taper Down Your Microdose So You Feel Happier Again

    This Is Your Brain On Shrooms
  • I recommended that he take 2 days off right away.
  • After 2 days off, cut back the dosage to 300 mg and take it for 4 days.
  • Take 3 days off.
  • Take 100 mg for 5 days.
  • Take 2 days off.
  • Repeat steps 8 and 9 for a month or more and see what happens. Consider taking a week or more off after a few months of microdosing just to check in with yourself and see how you are feeling.
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    Why ‘shrooms Can Lead To Mystical Experiences

    If you’ve ever had a trip where you felt connected to the truths of the universe, the default mode network or DMN, might be responsible. It’s the network of brain regions that helps with things like higher-level memory. “Under normal conditions, different regions of the brain work closely together as functional networks,”Meg Spriggs Ph.D, a post-doctoral researcher at the Centre for Psychedelic Research at Imperial College London, tells Bustle. “But under the influence of psychedelics , these networks begin to disintegrate, and we start to see an increase in global connectivity.” The opening up of brain networks might lead to all the mystical experiences that people have when they’re tripping out.

    Spriggs says that this “rebooting” of the brain’s networks could help with mental health disorders. “With a disintegration of brain networks comes a relaxation of a person’s prior beliefs,” she says. “This then breaks the shackles of rigid thought patterns.”A study published in Nature in 2017 from the Imperial College team found that this “resetting” might be a big part of psilocybin’s positive effects on people with treatment-resistant depression.

    How Avoiding A Conversation With Your Doctor About Microdosing Could Hurt You

    Physically, psychedelics are one of the least toxic drugs known and even at high doses, physical effects appear minor. Microdosing alleviates the psychological risks with the exception of building up tolerance.

    Talking to your doctor about psychedelics might not be the easiest subject to bring up but it is important to be honest about whether you are considering starting or have started microdosing with your doctor, especially if:

    • You have ever had a medical condition or have a medical condition
    • You are taking any prescription medications

    It shouldnt come as a surprise that since microdosing doesnt fall into the paradigm of Western medicine, your medical doctor may not be overly warm to the idea.

    The fact is that microdosing magic mushrooms isnt for everyone and there are certain medical conditions that may make you a poor candidate for microdosing. Keep your chin up though friend. Lets remember that when it comes to mental health, there are professionals who understand much more about psychedelics than general practitioners. Ask for a referral to a psychiatrist. Even better, ask for a referral to a psychiatrist who has experience treating patients with psychedelics.

    Remember, just because one professional doesnt have the experience or desire to help you learn more about microdosing magic mushrooms, doesnt mean the door is closed.

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    Psychedelic Spurs Growth Of Neural Connections Lost In Depression

    The psychedelic drug psilocybin, a naturally occurring compound found in some mushrooms, has been studied as a potential treatment for depression for years. But exactly how it works in the brain and how long beneficial results might last is still unclear.

    In a new study, Yale researchers show that a single dose of psilocybin given to mice prompted an immediate and long-lasting increase in connections between neurons. The findings are published July 5 in the journal Neuron.

    We not only saw a 10% increase in the number of neuronal connections, but also they were on average about 10% larger, so the connections were stronger as well, said Yales Alex Kwan, associate professor of psychiatry and of neuroscience and senior author of the paper.

    Previous laboratory experiments had shown promise that psilocybin, as well as the anesthetic ketamine, can decrease depression. The new Yale research found that these compounds increase the density of dendritic spines, small protrusions found on nerve cells which aid in the transmission of information between neurons. Chronic stress and depression are known to reduce the number of these neuronal connections.

    For some people, psilocybin, an active compound in magic mushrooms, can produce a profound mystical experience. The psychedelic was a staple of religious ceremonies among indigenous populations of the New World and is also a popular recreational drug.

    Some Researchers Think Shrooms Could Also Help Relieve Anxiety After They’re Used

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    For a New York University study looking at how the drug might affect cancer patients with severe anxiety, researchers observed the effects of psilocybin on volunteers who received either a dose of psilocybin in pill form or a placebo. A re-enactment of the procedure is shown in the photo above.

    Nick Fernandez, a 2014 participant, says his trip took him on an emotional journey that helped him see “a force greater than ,” he told Aeon Magazine. “Something inside me snapped,” and I “realize all my anxieties, defenses, and insecurities weren’t something to worry about.”

    NYU psychotherapist Jeffrey Guss told the New Yorker that many partipants experienced a similar result, and added that “We consider that to be part of the healing process.”

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    Long Term Effects Of Shrooms On The Brain

    There havent been many recent studies on the effects of shrooms, mostly because they are considered illegal substances with no medical purpose. Because of this, its difficult to say what the long term effects of shrooms on the brain really are. The experience of tripping, especially a bad trip, can trigger feelings of depression, anxiety, or psychosis in extreme cases. Its unknown whether the psilocybin causes those symptoms or whether mental illness was already present.

    There have been a handful of studies, however, that suggest shrooms could cause positive long term effects on the brain. One study showed that psilocybin caused long term, and perhaps permanent, changes to a users personality by making them more open to new experiences and more empathetic. Another study showed that shrooms helped lessen the depression and anxiety of terminal cancer patients for at least several months after taking them. Its important to note that these studies were performed in very controlled environments to minimize the risk of a bad trip as much as possible.

    Why The Walls Start To Melt On Magic Mushrooms

    The psychedelic effects of mushrooms might start in the brain’s thalamus, which filters all the information you receive from the outside world. “Some have proposed that psychedelics turn off this gating mechanism,” Doss says. This doesn’t mean you tune into parts of the universe that aren’t there, but rather that your brain can’t figure out what to pay attention to. It could be why you experience what Dr. Sansom calls “perceptual distortions,” where things bob up and down or change colors.

    Katrin Preller Ph.D., a researcher on psilocybin at Yale School of Medicine, tells Bustle that her studies have shown that when you’re high, the thalamus also tends to communicate more with sensory regions of the brain, devoted to things like taste and smell. Your trip’s weird sensations could just be the thalamus taking in every bit of information around, rather than sorting it nicely as usual.

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    Some Drugs Sold As Magic Mushrooms Are Actually Fake

    Because magic mushrooms are illegal in most countries and not regulated like other pharmaceuticals, there is no way to tell what you’re getting when you buy a batch of mushrooms.

    “Some drugs sold as ‘magic mushrooms’ have turned out to be store-bought mushrooms laced with another hallucinogen such as PCP or LSD, or a different drug entirely,” warned Dr. Weinstein.

    This means that purchasing magic mushrooms carries the risk of ingesting a range of other drugs, some of which may carry the very real risk of a fatal overdose or bad reaction. If you’re worried about the authenticity of a psilocybin mushroom, it’s better to not risk ingesting it.

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