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How Does Wellbutrin Work In The Brain

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    You Don’t Even Want To Think About Food

    #MentalHealth Update: other side effects of the Wellbutrin have kicked in. Namely: not feeling hungry, better focus. 😀

    Davey Shafik

    While its less common, diminished hunger and weight loss can come with Wellbutrin use, too, says Ackerman. But this side effect, and a dampened sex drive, are actually more common with other antidepressants, specifically SSRIs, adds Ackerman.

    Does Wellbutrin Cause Or Treat Anxiety

    About 2% of people stop taking Wellbutrin shortly after starting it because of anxiety-related side-effects. Such symptoms including anxiety, feeling restless, unable to sleep, and shaking may occur if the dosage is increased too quickly.

    Conversely, there is some preliminary research and anecdotal evidence that bupropion may help with anxiety in some people. In fact, there are doctors who prescribe Wellbutrin off-label for anxiety disorders.

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    Common Side Effects Of Wellbutrin Vs Prozac

    The most common side effects of Wellbutrin are dry mouth, nausea, dizziness, insomnia, stomach upset, anxiety, palpitations, and sweating. Wellbutrin may also cause muscle aches, rash, and itching. Weight changes have also been reported while using Wellbutrin. However, Wellbutrin is more likely to cause weight loss than weight gain.

    The most common side effects or Prozac include sexual dysfunction, decreased sex drive, diarrhea, indigestion, nausea, fatigue, dizziness, and drowsiness. Prozac may also cause rash, flu-like symptoms, and tremors. Weight changes have also been reported with Prozac.

    Severe side effects of Wellbutrin and Prozac include worsened depression and suicidal thoughts or behaviors. Seek immediate medical attention if you experience worsened depression symptoms. You should also seek medical attention if you experience an allergic reaction to Wellbutrin or Prozac. Symptoms of an allergic reaction include hives, trouble breathing, or swelling of the face or throat.


    Source: DailyMed , DailyMed

    Why Does It Take So Long For Antidepressants To Work

    Mechanism of action of Bupropion

    It takes so long for antidepressants to work because of their mechanism of affecting ones nervous system. The drugs used to combat depression are , which means selective serotonin reuptake inhibitors. Generally, when you start this drug treatment, it takes several days or even weeks to take effect and this is often a cause of frustration and despair for some people.

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    Bupropion Mechanism Of Action

    Bupropion class is a norepinephrine-dopamine reuptake inhibitor . According to a study about the pharmacology and therapeutic applications of bupropion, its mechanism of action is known for inhibiting the reuptake of the neurotransmitters dopamine and norepinephrine. It works by binding with the norepinephrine transporter and dopamine transporter .These neurotransmitters help in regulating sleep, mood, pleasure, memory retrieval, arousal, and restlessness. When these neurotransmitters are decreased, this results in depression, seasonal affective disorder , and other depressive disorders.Wellbutrin works by inhibiting dopamine and norepinephrine reuptake resulting in a longer duration for them to act in the brain. This helps in reversing the effects of depression.Unlike Selective Serotonin Reuptake Inhibitors mechanism of action, when using Wellbutrin, serotonin reuptake is not inhibited. This results in much lesser Wellbutrin sexual side effects, which are typical when a patient is taking SSRIs, but problems with weight gain, are still present.

    Medications That Interact With Effexor

    Serotonin syndrome is a condition in which abnormally high levels of serotonin accumulate in your body. This can happen when you take more than one medication that increases your serotonin levels.

    The following medications may cause serotonin syndrome if taken with Effexor:

    Taking Effexor with blood thinners or nonsteroidal anti-inflammatory drugs may increase your risk of bleeding.

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    You’re Feeling More Anxious Than Usual

    been on wellbutrin for a month and either i lost weight or the anxiety gave me abs

    darling homie forever

    Doctors may choose Wellbutrin for patients whose depression symptoms are more melancholic or sluggish, says Ackerman, because it can give patients a boost energy-wise. It can be like an extra cup of coffee, she says.

    Some women, however, may find it actually revs them up too much, increasing anxiety. If that happens, talk with your doctor right away about trying a new drug, advises Ackerman.

    What Drugs Interact With Wellbutrin

    Bupropion (Wellbutrin) : Meds Made Easy (MME)
    • Bupropion should be used cautiously in patients receiving drugs that reduce the threshold for seizures. Such drugs include prochlorperazine , chlorpromazine , and other antipsychotic medications of the phenothiazine class. Additionally, persons who are withdrawing from benzodiazepines are at increased risk for seizures.
    • Carbamazepine may reduce the effect of bupropion by reducing the blood concentration of bupropion. Monamine oxidase inhibitors should not be combined with bupropion because of the risk of severe reactions. At least 14 days should elapse between discontinuation of an MAOI and initiation of bupropion. Bupropion may affect the action of warfarin .
    • Ritonavir may increase the breakdown and elimination of bupropion. In some studies ritonavir reduced the concentration of bupropion in the body by 22% to 66%.

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    Is Wellbutrin Or Prozac More Effective

    Wellbutrin and Prozac are effective prescription medications for treating depression. The best antidepressant will depend on a number of factors such as cost, individual response to treatment, and potential side effects. Consult a healthcare provider on the best treatment options for your condition.

    According to one double-blind comparison study, bupropion and fluoxetine were found to be similar in effectiveness for the treatment of depression. The study was conducted over seven weeks and utilized the Hamilton Rating Scale for Depression among other tools to assess treatment efficacy. Both bupropion and fluoxetine helped relieve depression symptoms with no severe adverse effects.

    One systematic review found that Wellbutrin is an effective and safe medication compared to other antidepressants. Wellbutrin may have less side effects compared to SSRIs. It also causes less sexual side effects and weight gain than other antidepressants.

    A systematic review found that Prozac is an effective medication for several mental health conditions, including depression, bulimia, and OCD. Prozac was found to be more effective than placebo in some studies within the review. It was also found to be as effective as Anafranil for treating OCD.

    The Following Provides More Information About Wellbutrin In General And Also Highlights How Marijuana And Wellbutrin Could Interact With One Another

    When people are prescribed to certain medicines, its extremely important that they know the potential symptoms, side effects and risks, and also that they know how medications could interact with other substances, such as alcohol.

    With the legalization of recreational marijuana currently on the books in several states across the country, this is also a key potential interaction that should be considered when someone starts a new medication.

    What about marijuana and Wellbutrin? How does marijuana affect Wellbutrin?

    The following provides more information about Wellbutrin in general and also highlights how marijuana and Wellbutrin could interact with one another.

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    Is Wellbutrin Or Prozac Better

    Wellbutrin and Prozac are similarly effective for treating depression. The best antidepressant is the one that causes the least side effects and is more cost effective, depending on the situation. Wellbutrin causes less sexual side effects and weight gain than SSRIs like Prozac. Other SSRIs include Paxil , Zoloft , Lexapro , and Celexa . Prozac may be more appropriate than Wellbutrin to treat depression in an individual with bipolar disorder, bulimia, or OCD. Antidepressant medications often work better in combination with psychotherapy.

    The History Of Wellbutrin

    SNRIs (Serotonin Norepinephrine Reuptake Inhibitors ...

    Wellbutrin is the brand name for the drug bupropion. It was approved by the Food and Drug Administration to treat depression in 1985. From 1986 to 1989, it was removed from the market due to reports of epileptic seizures. The seizures were found to be dose-related, so when Wellbutrin returned to the market in 1989, the maximum dose was lowered.

    Wellbutrin SR, the sustained-release version, was approved in 1996, and Wellbutrin XL, the extended-release version, in 2003. In 2006, it became the first medication approved to treat seasonal affective disorder .

    The FDA has not approved Wellbutrin for the treatment of ADHD. However, it is prescribed by doctors as an off-label treatment option.

    Research on Wellbutrin for ADHD is ongoing. For example, one study found it significantly lessened ADHD symptoms when compared to a placebo. Other studies on the effectiveness of Wellbutrin in aiding ADHD symptoms in adults have been promising.

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    Effexor Vs Wellbutrin: Differences Similarities And Which Is Better For You

    Drug overview & main differences | Conditions treated | Efficacy | Insurance coverage and cost comparison | Side effects | Drug interactions | Warnings | FAQ

    Effexor and Wellbutrin are two different antidepressant medications that can be used to treat depression. Both Effexor and Wellbutrin work by boosting specific neurotransmitters, such as norepinephrine and dopamine, in the brain. Balancing these neurotransmitters can help improve mood, promote better sleep, and boost your appetite and focus. Antidepressants are also useful for treating other mental health problems in addition to major depression.

    Despite their similarities, Effexor and Wellbutrin work differently and are FDA approved to treat different conditions.

    You’ve Got Tons Of Energy All Of A Sudden

    This can be a perk of the drug for women who want to feel more energized. But Ackerman warns: Theres a risk of flipping someone into hypomania or mania if they have an underlying bipolar disorder.” It’s for this reason, Ackerman adds, that Wellbutrin wouldn’t be used in bipolar patients, unless it was paired with a mood stabilizer.

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    Noradrenaline And Dopamine Reuptake Inhibitors


    Noradrenaline and dopamine reuptake inhibitors are agents that inhibit the reuptake of both dopamine and norepinephrine. The NDRIs fall under a broader classification of atypical antidepressants, so named because they do not fit into any of the other antidepressant classes.




    Bupropion is extensively metabolized, primarily through the CYP2B6 isozyme.



    Seizures: Bupropion may lower the seizure threshold, so it must be avoided in individuals with a history of seizures or who are prone to seizures:

    Patients undergoing drug or alcohol withdrawal

    Prior diagnosis of bulimia or anorexia nervosa

    MAOIs: MAOIs inhibit the breakdown of neurotransmitters such as dopamine and norepinephrine. Simultaneous inhibition of the reuptake and breakdown of these neurotransmitters can lead to complications such as hypertensive crisis.

    Thioridazine: Bupropion may inhibit the metabolism of thioridazine, increasing the risk of ventricular arrhythmia and sudden cardiac death caused by elevated thioridazine levels.

    Side Effects

    Dry mouth may be caused by increased noradrenergic transmission.

    Nausea is a frequent side effect of dopaminergic agents, likely through a central effect.

    Insomnia may occur due to the stimulating effects of enhanced NA.

    Rare, Serious

    Seizures: A small risk of seizures has been observed with the use of bupropion. The risk increases with higher doses.

    Important Notes



    Weight Loss Side Effect Or Additional Benefit

    Wellbutrin XL Update: 2 weeks

    It is enough to read the extensive list of possible side effects of any antidepressant to confirm that weight loss is found in most of them, typified as anorexia or loss of appetite. The problem with Wellbutrin is that it is being sold as a bonus rather than as a possible side effect.

    Chemistry, in this case, does it a disservice. Wellbutrin is a derivative of diethylpropion, an amphetamine anorectic . But, being a derivative, its effects and power of action, both in this aspect and in others, are very different. The incidence of loss of appetite in patients treated with Wellbutrin occurs only in 18% of cases.

    There are independent scientific studies that corroborate it and have investigated long and hard about this effect so often associated with antidepressants. And although Wellbutrin was associated with less weight gain than tricyclic antidepressants, no significant difference was observed between patients treated with Wellbutrin, SSRIs , and placebo.

    The largest study was published in 2005 by the Division of Medical Policy and Evaluative Sciences, University of North Carolina. It established a systematic and scientific comparison of the results of 46 studies from both medical laboratories and scientific entities.

    Among its conclusions, the aspect of weight loss is discussed and it affirms that of all the antidepressants analyzed, weight loss is more frequent with fluoxetine and fluvoxamine, although during long-term treatment, this effect usually disappears.

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    Bupropion For Smoking Cessation

    Studies reveal bupropion to be a great aid for smoking cessation as it helps reduce nicotine withdrawal and cravings to a great extent.

    The type of bupropion used for smoking cessation is sold under the brand name of Zyban. It is described as a safe and cost-effective treatment for nicotine addiction. Zyban helps around one in 5 people quit smoking in the U.S each year. The effectiveness of this medication as an aid against nicotine dependence increases when bupropion is used in conjunction with other nicotine replacement products such as the nicotine patch, gum, and lozenges. However, Zyban may only be recommended for people who smoke ten or more cigarettes per day.

    What Are The Main Differences Between Wellbutrin And Prozac

    Wellbutrin is an aminoketone antidepressant that is also known by its generic name, bupropion. The exact way in which Wellbutrin works is not well understood. However, it is believed to increase levels of certain neurotransmitters called norepinephrine and dopamine in the brain. Individuals with depression may have an imbalance of these neurotransmitters. Unlike other commonly prescribed antidepressants, Wellbutrin has no effect on serotonin levels.

    Wellbutrin is available in three different formulations: immediate-release , sustained-release , and extended-release . Depending on the dosage form, Wellbutrin can be taken once, twice, or three times daily. The active ingredient in Wellbutrin, bupropion, is also marketed as Zyban to support smoking cessation.

    Prozac is one of the most commonly prescribed antidepressants. It is also known by the generic name fluoxetine. Prozac belongs to a class of drugs called selective serotonin reuptake inhibitors . These drugs work by increasing levels of the neurotransmitter serotonin to ease symptoms of depression.

    Prozac comes as a daily oral capsule. The exact dosage depends on the condition being treated. Prozac is also available as a delayed-release capsule that is taken once per week.

    Differences between Wellbutrin and Prozac
    Adults children 8 years and older

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    Drug Interactions Of Wellbutrin Vs Prozac

    Wellbutrin should not be combined with a monoamine oxidase inhibitor , such as selegiline or phenelzine. Taking Wellbutrin with an MAOI can increase the risk of high blood pressure. Prozac should also be avoided with an MAOI. Combining Prozac with an MAOI can increase the risk of serotonin syndrome, a condition that may require hospitalization. Wellbutrin or Prozac should also not be taken within 14 days of stopping an MAOI.

    Dopaminergic drugs like levodopa and amantadine can interact with Wellbutrin. Using these medications with Wellbutrin can increase the risk of adverse effects, such as restlessness, dizziness, and tremors.

    The use of nonsteroidal anti-inflammatory drugs or warfarin should be avoided or monitored while taking Prozac. This drug interaction may lead to an increased risk of bleeding.

    Prozac can also interact with other serotonergic drugs like certain opioids, tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors , seizure medications, and mood stabilizers. Taking these medications with Prozac may increase the risk of serotonin syndrome.


    *Consult a healthcare professional for other drug interactions

    Norepinephrine And Dopamine Reuptake Inhibitors

    Wellbutrin Uses Side Effects Dosages Precautions

    While these drugs are effective in treating depression, their use is associated with certain side effects, withdrawal, and some risk of overdose. Though the risk is far lower than that of certain other drugs of abuse, there is potential for misuse of these drugs, which could increase the risk of seizures, heart problems, and other health concerns.

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    Can You Stop Taking Bupropion

    Like other widely used antidepressants, bupropion has the potential to cause certain withdrawal symptoms if you suddenly stop using it without tapering your dosage.

    Common bupropion withdrawal symptoms of bupropion include difficulty sleeping, balance issues, anxiety, depression, mood changes, flu-like symptoms, sweating and more.

    If youre prescribed bupropion and no longer want to use it, do not suddenly adjust your dosage or stop taking your medication. If youre prescribed other medications to take at the same time as bupropion, including other antidepressants, continue taking these medications as normal.

    Instead, talk to your healthcare provider about adjusting your dosage, safely tapering your bupropion dosage over time or changing to a different antidepressant or smoking cessation aid.

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