Simple Alternative To Gene Therapy
Prof. Chen and his colleagues have been working on regenerating neurons for some time. Before turning to chemical reprogramming, they had experimented with gene therapy.
However, they concluded that a gene therapy approach, which could cost around $500,000 per person, would be too expensive. In addition, delivery of gene therapy requires sophisticated, advanced techniques and expertise.
Prof. Chen explains that the main advantage of the chemical programming approach is that a pill containing small molecules could be distributed widely in the world, even reaching rural areas without advanced hospital systems.
Also, he and his team found that injecting the four drugs into adult mice increased the generation of new brain cells in the hippocampus, which is a region of the brain that plays a role in memory.
Independance Motivation And Hope
My son Sharat suffered a severe traumatic brain injury 23 years ago leaving him with Aphasia and right sided weakness from his vision,hearing to his limbs. The lockdown in June was a great challenge for him as his caregivers stopped coming, no gym workouts and no outings for a coffee.
Being his mother and primary carer I feared that this was a hotbed for depression. I scoured the net and chanced upon FlintRehab. As there was a trial period it was safe for us to risk getting it across to Auckland.
His OT checked it out and felt that it was ideal. I can honestly second this.
He enjoys working on it and now after three months can do it on his own. His left hand helps his right hand. The FitMi video explains and shows him what to do, it gives him marks and applauds him too!!
He has to use both sides of his brain. The caregivers are OT students who returned enjoy working on it with him.
In three months there motivation built up in him with a drive to use his right hand. There is definitely a slight improvement in his right hand.
This encourages him as well as the caregivers to try harder.His overall mood is upbeat. He enjoys it, so much so, that it doesnt matter if his caregiver is away.
FitMi is a blessing.
New Technology ‘retrains’ Cells To Repair Damaged Brain Tissue In Mice After Stroke
Scientists at The Ohio State University Wexner Medical Center, College of Engineering and College of Medicine have developed technology to “retrain” cells to help repair damaged brain tissue.
video: A new cell therapy technology offers hope for unprecedented recovery, even days after a stroke.view more
COLUMBUS, Ohio – Most stroke victims don’t receive treatment fast enough to prevent brain damage. Scientists at The Ohio State University Wexner Medical Center, College of Engineering and College of Medicine have developed technology to “retrain” cells to help repair damaged brain tissue. It’s an advancement that may someday help patients regain speech, cognition and motor function, even when administered days after an ischemic stroke.
Engineering and medical researchers use a process created by Ohio State called tissue nanotransfection to introduce genetic material into cells. This allows them to reprogram skin cells to become something different – in this case vascular cells – to help fix damaged brain tissue.
Study findings published online today in the journal Science Advances.
In this mouse study, cells were ‘pre-conditioned’ with specific genes and injected into the stroke-affected brains, where they promoted the formation of new blood vessels via reprogramming and the repair of damaged brain tissue.
You May Like: Is Prevagen Safe For Diabetics
A Lot More Work Ahead
The study authors point out that the findings are just one step forward toward neuron regeneration in a pill. There is still a lot of work to do in developing the right formula, particularly regarding the packaging and delivery of the small molecules.
As well as confirming their effectiveness, the researchers also need to explore the side effects and safety of the drugs.
They are confident, however, that their new four-drug formula will one day realize its potential as a straightforward treatment for people who lose neuronal function through brain injury, stroke, and neurodegenerative conditions such as Alzheimers disease.
My ultimate dream is to develop a simple drug delivery system, like a pill, that can help stroke and Alzheimers patients around the world to regenerate new neurons and restore their lost learning and memory capabilities.
Prof. Gong Chen
Can You Repair Damaged Brain Cells
Brain healing is the process that occurs afterthe brain has been damaged. If an individualsurvives brain damage, the brain has a remarkableability to adapt. When cells in the brain aredamaged and die, for instance by stroke, there willbe no repair or scar formation for thosecells.
Similarly, it is asked, can brain cells grow back if they are damaged?
Brain damage could be repaired by creatingnew nerve cells. Usually almost no new neurons are grown inthis area of the brain in adults, so once the cellsare damaged or die, they are notreplaced.
Likewise, can you reverse brain damage? Some people with brain damage experiencepermanent disability but can recover partially from theirinjury. If neurons are damaged or lost, theycan‘t grow back — but the synapses, or connections betweenneurons, can. Essentially, the brain creates newpathways between neurons.
Beside this, can the brain heal itself after damage?
The brain does have a limited ability to healitself. Recent research indicates the brain can repairor grow new brain cells to a very limited extentafter a brain injury, but much of the recoveryexperienced is due to the brain ‘rewiring’ itself andslowly using other pathways to bypass brokenconnections.
How can I repair my brain damage naturally?
10 Ways to Help Your Brain Heal
Read Also: Brain Eating Amoeba From Shower
Ways To Fix Neurotransmitter Problems
1. Taper Off or Avoid Anti-Depressants
Prozac, Sarafem, Paxil, Zoloft, Celexa, Lexapro, Effexor, Cymbalta, Pristiqthe list of popular anti-depressant drugs goes on and on with hundreds of millions of prescriptions handed out and billions of dollars in sales.
I wouldn’t even include this issue in the book unless I had personally done consults with many very active individuals who are either on anti-depressants, depressed, or showing signs of depression. Perhaps it’s the nature of the beast us physically active people tend to rely on exercise for a high, and when that’s missing or we’re not fulfilled by it anymore, we can tend to get down. And at that point, anti-depressants may seem like an attractive solution.
Now I’m not a doctor and I’m not recommending that if you’re on an anti-depressant you quit cold turkey, but if you want to gradually taper yourself off these medications, you should certainly pay attention to the other 7 ways you can address neurotransmitter issues
Here’s why anti-depressants are such a problem: they work in one of two ways either by increasing the brain levels of serotonin or they block re-uptake of serotonin. That is why most of them are called SSRI’s, or Selective Serotonin Reuptake Inhibitors.
These SSRI’s cause a short term flooding of the brain with serotonin, as well as a very fast degrading or breaking down of serotonin as it is left to hang around in the synaptic cleft.
2. Moderate Stimulants
The Two Ways Your Brain Breaks
As you now know, it’s very obvious that your brain is the primary determinant of where your true performance capabilities lie not to mention that a well-functioning, optimally tuned brain is also pretty darn important when it comes to your quality of life, your work productivity, your communication skills, your problem solving abilities and much more.
But unfortunately, most of us walk around with broken, inflamed, poorly functioning and poorly trained brains. This is usually due a combination of two factors:
1. Neurotransmitter Problems
2. HPA Axis Dysfunction
If both these issues are addressed, then your brain tissue, nerve cells and neurons will be healthy enough to optimally process information and seamlessly communicate with your body during a workout or a race, healthy enough for you to train your brain to resist getting distracted by morning work or tempting foods, and healthy enough for your mind to allow you to experience huge mental and physical performance breakthroughs.
So let’s learn how to fix both these issues, shall we?
Recommended Reading: Does Crossword Puzzles Help Brain
Regular Movement And Exercise
As youve learned earlier, regular movement and exercise are not only part of a healthy lifestyle, but are essential for brain health. They may help to lower chronic inflammation, reduce stress levels, and decrease the risk of memory problems, learning troubles, and cognitive decline.
I recommend that you exercise at least 20 to 30 minutes minimally 5 times a week. Try a combination of cardiovascular exercise, strength and resistance training, and low-impact exercise. Aim to stay active throughout the day by choosing to take the stairs, taking a walk at lunch, stretching regularly, gardening, and dancing for your favorite song.
Reduce Stress And Practice Gratitude
Reducing your stress levels is non-negotiable for brain regeneration and mental health. To reduce your stress, try regular meditation, daily prayer, breathwork, journaling, regular exercise, relaxation recordings, daily gratitude, and nature walks. Practice positive self-talk and affirmations for a powerful mindset and mood shift.
Practice daily gratitude and prayer. Keep a daily gratitude journal and count your blessing throughout the day. Remember, when you are in a state of gratitude, negative energy, stress, and anxiety have no room.
Recommended Reading: How To Balance Brain Chemicals Naturally
Speak To An Addiction Recovery Expert Now Available & Answered 24 Hours:
Drug use can affect every part of your life. Addiction may impair the health of your body, interfere with your relationships, and change the way you perceive the outside world. One of the most damaging side effects of drug abuse is damage to your brain. If youve misused prescription drugs, heroin, cocaine, stimulants, depressants, hallucinogens, or other types of drugs, your brain may have sustained a considerable amount of harm. The good news is that your brain can heal itself when you stop using drugs but you must create the right conditions to do so. When you do, the brain can re-establish its chemical balance. Once balanced, your brain can begin to regain control of your impulses, emotions, memory, thinking patterns, and mental health.
Grow And Maintain New Brain Cells With A Mental Workout
One of the most fascinating examples of neurogenesis in action has been observed in the brains of London cab drivers.
London cabbies give their brains a tremendous workout by memorizing the streets and landmarks of London.
Using MRIs, researchers discovered that the hippocampus of a typical London cabbie is significantly larger than that of their non-taxi-driving peers. 01267-X” rel=”nofollow”> 54)
The hippocampus is the part of the brain responsible for storing and organizing memories and for spatial navigation.
But, you dont have to memorize the 25,000 streets and 20,000 landmarks in London to grow your hippocampus.
Any time you challenge your brain with something thats new and complex, it helps build your brain in two ways.
It stimulates the formation of new brain cells, and it assures that new ones stick around.
For the brain, as for muscles, use it or lose it applies.
Any brain cells or neural connections that are not regularly used are allowed to die.
Recommended Reading: Airpods Cause Brain Cancer
Nerve Cells Have Trouble Regrowing Damaged Parts
Looking at the structure of a neuron, you will notice it has a cell body and several arms that it uses to connect and talk with other neurons . The really long arm that sends signals to other neurons is called axon, and axons can be really long. If an axon is damaged along its way to another cell, the damaged part of the axon will die , while the neuron itself may survive with a stump for an arm. The problem is neurons in the central nervous system have a hard time regrowing axons from stumps. Why do skin cells not have this problem? Skin cells are much simpler in structure. And because they can give birth to entirely new cells, they dont face the problem of having to repair parts of their cells.
- Figure 1
- Left: the structure of a brain cell. Note the branch-like arms that extend from the cell body . These arms receive incoming signals. The really long arm that extends to the bottom right is called the axon, which sends signals to a receiving cell. The axon is enveloped by a myelin sheath , which helps signals travel faster along the axon to the receiving cell. Right: when an axon gets injured, the end part dies off and leaves an axon stump. Stumps have a hard time to grow back after injury.
So, why do damaged neurons have trouble regrowing axons?
- Figure 2
- Growing axons looking for new target cells to connect with have a hard time in an injury environment. This is partly due to star-shaped support cells , which spit out chemicals . These chemicals stop axon growth.
When Damaged The Adult Brain Repairs Itself By Going Back To The Beginning
- University of California – San Diego
- When adult brain cells are injured, they revert to an embryonic state, say researchers. In their newly adopted immature state, the cells become capable of re-growing new connections that, under the right conditions, can help to restore lost function.
When adult brain cells are injured, they revert to an embryonic state, according to new findings published in the April 15, 2020 issue of Nature by researchers at University of California San Diego School of Medicine, with colleagues elsewhere. The scientists report that in their newly adopted immature state, the cells become capable of re-growing new connections that, under the right conditions, can help to restore lost function.
Repairing damage to the brain and spinal cord may be medical science’s most daunting challenge. Until relatively recently, it seemed an impossible task. The new study lays out a “transcriptional roadmap of regeneration in the adult brain.”
“Using the incredible tools of modern neuroscience, molecular genetics, virology and computational power, we were able for the first time to identify how the entire set of genes in an adult brain cell resets itself in order to regenerate. This gives us fundamental insight into how, at a transcriptional level, regeneration happens,” said senior author Mark Tuszynski, MD, PhD, professor of neuroscience and director of the Translational Neuroscience Institute at UC San Diego School of Medicine.
Don’t Miss: Does Prevagen Help With Memory Loss
Repairing Damage From Substance Abuse
One of the most common schools of thought regarding drug users and ex-addicts was that the damage they have done to their brains is irreversible.
Now, research is showing that recovering addicts and others are having success fixing damage done to their brains with neurogenesis. Some report success with correcting emotional problems, others report cognitive deficits disappearing.
Use Autophagy Enhancing Herbs
Autophagy is your bodys natural method of detoxification. It allows your body to recycle and get rid of old and unhealthy cells leaving room for the creation of new and healthy cells to replace them. To heal your brain cells, I recommend autophagy-enhancing herbs, including matcha green tea, ginger, turmeric, resveratrol, citrus bergamot, oregano, sage, rosemary, and quercetin.
This is why I recommend Inflam Defense, a powerful supplement made with turmeric, ginger, boswellia, quercetin, rosemary, and rutin. To learn more about the top autophagy-enhancing herbs, I recommend this article.
Also Check: Cebria For Memory Loss
Why Dont Current Treatments For Brain Damage Work
Not only are all the brain cells and brain areas interconnected in very complex ways, but their position vis-a-vis one another is also very complex. There are probably several hundred different kinds of cells in the brain and the neurons, which are the work horses of the brain, have to be positioned in very particular ways. There are six layers of each brain region each layer of the cerebral cortex is populated by a different kind of neuron. If that layering gets disrupted, you get problems such as epilepsy.
To repair the adult brain, not only does it have to generate the neurons, but it has to segregate and position them appropriately. So far that has not been achieved through either natural repair mechanisms or by human intervention.
To repair the adult brain, not only does it have to generate the neurons, but it has to segregate and position them appropriately.
Another major reason brain disease is difficult to treat is that drugs do not penetrate the brain easily because it is encased by the blood-brain barrier. A whole class of pharmacological research is working on getting past the blood-brain barrier. Both the penetration of drugs and the very intricate anatomical positioning of the different cell types are very important but unsolved issues in CNS treatment.
What Is Brain Regeneration
Your brain is one of your most important organs. It is the center of all of your bodys functions and systems. It serves as a command center for your nervous system that perceives stimuli, activates responses, and obtains and sends signals across your body to keep you safe and healthy. Your brain is also the place where your memory is stored and learning, cognition, and individual growth is happening.
Clearly, the health of your brain is critical and should be protected. You may think that it is normal for your brain to decline with age, however, that is not necessarily the case. Nutrition, lifestyle habits, and other factors all affect your brain health. More importantly, and contrary to old beliefs, your brain is able to generate new brain cells.