The Short Term Effects Of Marijuana Vary
Although the exact same biological processes occur in everyone who smokes or consumes cannabis, the way those processes make people feel varies wildly.
Some people are incredibly sensitive to THC while others are less sensitive, Gruber says. Some get very paranoid others have no problem. Some people say oh my god, I got so hungry and ate everything in the house while others dont get hungry at all. If someone hands you a bowl or a vape cartridge of Granddaddy Purple, you will very likely have a different experience than they do, even though youre smoking the same stuff.
There are many potential reasons for this. So much of it depends on previous use history, whether you have some familiarity with THC and other substances, Gruber says. It also depends on your individual body chemistry and metabolism, as well as the product itself, whether its a cultivar that has high amounts of other cannabinoids that mitigate the effects of THC.
Another factor is how activated a persons endocannabinoid system is before they use cannabis. Lets say 70 percent of your receptors are activated and only 20 percent of that persons receptors are activated right before they use marijuana, Piomelli says. Because of this difference, you might become panicky after smoking while the other person feels more relaxed. This also explains why the same person can feel different effects on different occasions even if they consume the same product both times.
Exogenous Cannabinoids And Their Receptors
The principal active component in the complex mixture of cannabinoids present in extracts of the plant Cannabis sativa is 9tetrahydrocannabinol . THC is a sticky resin that is not soluble in water. Smoking remains the most efficient means of delivering the drug and experienced users can titrate the dose by adjusting the frequency and depth of inhalation . THC or cannabis extracts can also be taken orally in fatcontaining foods or dissolved in a suitable pharmaceutical oil, but absorption is delayed and variable . A series of manmade synthetic cannabinoids, some of which are more potent and more water soluble than THC, is also available . All of these compounds act as agonists at the CB1 cannabinoid receptor , which is the only one known to be expressed in the brain. A second cannabinoid receptor, CB2, is expressed only in peripheral tissues, principally in the immune system . THC and the synthetic cannabinoids also act to some extent as agonists at the CB2 receptor. Both cannabinoid receptors are members of the Gprotein coupled class, and their activation is linked to inhibition of adenylate cyclase activity . A series of synthetic drugs is also now available that act as specific antagonists at CB1 or CB2 receptors . One of these compounds, rimonabant, which acts selectively to block CB1 receptors , has been widely used in studies of the actions of cannabinoids in the CNS .
Why Is Cbd Different From Thc And Other Cannabinoids
As we said, there is a notable difference between CBD and other cannabinoids, or chemicals that are found in both hemp and marijuana.
While all other active compounds of the plant interact with two cannabinoid receptors in the nervous system, CB1 and CB2, Cannabidiol has very little effect on both. CB1 receptors are found in different regions of the brain, including those responsible for controlling emotion, pain, cognition, and memory. CB2 receptors, on the other hand, regulate inflammatory responses and bolster the immune system.
Others spread myths about CBD over the internet that it interacts with the cannabinoid receptors, but they are completely mistaken. CBD stimulates the endocannabinoid system to produce more of its own cannabinoids and slows their breakdown. Delta-9-Tetrahydrocannabinol , on the other hand, binds to CB1 and CB2 receptors, activating them and thus changing a persons thinking, memory, pleasure, and pain perception, and concentration. These effects contribute to what we describe as a marijuana high.
Interestingly, CBD may also alter the effects of THCby blocking the CB1 receptors in places where THC taps. In higher doses, THC can induce anxiety and paranoia in some users, which is why many people are afraid to try weed. But strains that are high in CBD tend to mitigate these effects, allowing you to enjoy the benefits of marijuana without a disturbance.
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Is Cannabis Good For The Brain
Back in 1988, Francis Young, a DEA Administrative Law Judge responded to a petition to reclassify cannabis as a Schedule II substance, acknowledging the herbs medical value.
While the media and the available research seemingly go back and forth on the risks of cannabis, Judge Young was confident in the herbs safety and therapeutic application.
After strenuous research and review of the case, Judge Young ultimately recommended that the plant be rescheduled. He states,
one of the safest therapeutically active substances known to man. In strict medical terms, marijuana is far safer than many foods we commonly consume.
Now, nearly two decades later, there is far more information on the health risks of cannabis. Today, ample preclinical evidence suggests that compounds in the herb are:
All of these qualities suggest that the herb may possibly improve brain health in certain conditions. However, what those conditions are exactly are difficult to determine. In terms of occasional to moderate cannabis consumption, there is little evidence that the herb causes any sort of long-term damage.
Other than becoming dependent on cannabis, there is still no evidence of serious health harms caused by even chronic cannabis use. Though, studies like those cited in the above section suggest that harms may be possible.
Yet, for many, regular cannabis use can drastically improve quality of life and assist in healing in some mental and neurological conditions.
What Is Thc The Research Continues
People have used marijuana for centuries, totally unaware of the chemical inside that was responsible for its signature effects. After the THC molecule was discovered, cannabis use had become both stigmatized by some and celebrated by others and THC became synonymous with a way to get high.
In the decades since, THC has come into its own not just as a recreational drug, but as a fascinating compound with true medical potential. As legalization expands, so does the research into delta-9 tetrahydrocannabinol, its side effects, and how it might be used as a medical treatment. After thousands of years of use, its safe to say that scientists have only just scratched the surface of the potential contained in this famous cannabinoid.
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Which States Allow Medical Marijuana
Medical marijuana is legal in 33 states and the District of Columbia:
- West Virginia
States allowing legal recreational use include: Alaska, California, Colorado, Illinois, Maine, Massachusetts, Michigan, Nevada, Oregon, Vermont, and Washington
States that allow restricted use only include: Alabama, Georgia, Idaho, Iowa, Kentucky, Mississippi, Missouri, North Carolina,South Carolina, Tennessee, Texas, Virginia, Wisconsin and Wyoming.
How Does Marijuana Affect The Brain
As recreational Marijuana use becomes legalized throughout the US, many people now wonder how affects the brain and whether or not it kills brain cells. Just as years of heavy alcohol, Meth, and Heroin use can cause some irreversible brain damage, prolonged Marijuana abuse can affect the ability of brain cells to convey messages . Using Marijuana can cause damage to brain cells that results in a number of concurrent symptoms throughout the body.
Like other drugs, components of Marijuana bind with specific receptors in the brain. Tetrahydrocannabinol is Marijuanas primary Psychoactive ingredient, and it attaches to the brains Cannabinoid receptors . These receptors connect to nerves in the brain which govern memory, appetite, pain regulation, and mood.
When a person smokes Marijuana, they may notice they struggle with staying focused or recalling important details. This can worsen with prolonged Marijuana use, resulting in problems like poor memory and concentration. Motor skills can also be affected by the drug. If users decide to drive while high, they can endanger their lives and the lives of others.
Break free from addiction.
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The active chemical in cannabis is called THC. It speeds up thinning of a rats version of the prefrontal cortex. THC binds to docking stations in brain cells. Those docking stations are called CB1 receptors. That CB is short for cannabinoid , meaning these receptors are ideally structured to respond to cannabis compounds known as cannabinoids. These include THC.
Rats given THC during adolescence lose some brain connections that would otherwise stick around into adulthood. This can alter the rodents behavior and memory. How much depends on the amount of THC and the animals age.
Researchers cannot study a direct link between THC and prefrontal-cortex thinning in people. But Albaughs colleagues found more CB1 receptors, on average, in the prefrontal cortex of 21 adult men than in other brain regions.
It is notable that the CB1-rich part in adult brains overlaps with the area that thins faster in cannabis-using teens. The overlap does not prove that cannabis causes the change. It does, however, add to evidence that it may.
A window of vulnerability
It is critical to know if teen cannabis use may change how you function as an adult, says Ferland. Until more is known, many researchers recommend postponing any cannabis use until adulthood. They also suggest limiting its frequency and using only low-potency products.
What Happens When You Feel
How Cannabis Works In Your Brain
Humans have been using substances to alter our state of mind for centuries now. Our ancestors used different kinds of hallucinogenic plants, and today we have a plethora of ways to get high. Even the coffee and alcohol we consume gives us a sort of high, because they alter the chemical processes in the brain.
Then theres cannabis.
But how exactly does it work in the brain? Why does it make us feel so good while helping us treat a myriad of conditions including those affecting our mind?
To understand how cannabis works in the brain, first its important to learn about how the brain works. The brain has neurons, cells which transmit information in the brain by releasing neurotransmitters, which change the electrical charge of receiving neurons either by inhibiting or exciting it. When the neurons are excited, signals go through. All these signals work in conjunction with one another and its effects are compounded into various configurations just within milliseconds. This is basically how your brain works every time you breathe, think, or even move.
What Happens When You Smoke Pot?
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Ways That Marijuana Affects Cognition
Any type of prolonged use of a psychoactive substance has the potential to cause neurological imbalances or impairmentand marijuana is no exception. The exact nature and extent of brain damage or other lasting effects can depend on a number of factors including:
- Strength of the dosage
- Pre-existing mental illness or genetic predisposition to mental illness
Though marijuana may not be as overtly damaging as alcohol, meth, or cocaine , there are still plenty of undesirable cognitive side effects to be had.
Numerous studies conducted over the past few decades have found that years of chronic cannabis use resulted in significant reductions in gray matter volume. Gray matter is the neuron-dense part of our brain, which is largely responsible for our capabilities to learn and otherwise function. One particular study found that heavy cannabis use resulted in shrinkage of hippocampus and amygdala parts of the brain which can significantly impact memory and learning.
That same study found that the most significant factor was when those participants began using marijuana. Those who started smoking as adults rather than teenagers faced no decrease in IQ. Adolescents with their still-developing brains have the most to lose cognitively. Rather than killing off brain cells, however, marijuana impedes brain development, putting young adults at a number of neurocognitive deficits .
How Does Cannabis Work In The Brain
When consumers inhale or ingest cannabis, compounds in the herb tap into the endocannabinoid system to produce possible therapeutic effects. Since the ECS regulates such a broad range of bodily functions, cannabis compounds have a very wide range of therapeutic potential.
in the endocannabinoid system one of its main roles in the brain is to regulate neurotransmitter function and again, if theres too much of one kind of neurotransmitter it will bring it down, if theres too little it will bring it up.
Simply stated, the endocannabinoid system is a large regulatory network that works to create optimum balance in the mind and body. When compounds like THC or the second most popular cannabinoid, cannabidiol , interact with the ECS, they change the balance of the system as a whole.
Researchers like Russo theorize that a wide variety of conditions are caused by an imbalance or a deficiency of the endocannabinoid system.
Some symptoms of endocannabinoid deficiency include,
Several mood and mental health disorders have also been linked to possible imbalances of the endocannabinoid system. In a 2016 paper, Russo briefly speculates that conditions like PTSD and bipolar disorder may involve the ECS. Physical ailments like fibromyalgia, migraine, and irritable bowel syndrome are also thought to be involved.
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Is There A Health Downside To Cannabis
When it comes to concerns about cannabis and health, the herbs potential to be habit-forming is one of the biggest concerns for consumers, parents, and health professionals. Though, what cannabis dependence means in terms of long-term brain health is still to be determined.
Some estimates suggest that approximately 9% of cannabis consumers develop dependence, compared with 32% of tobacco smokers and 15% of alcohol consumers.
Research suggests that dopamine, the reward neurotransmitter, may be in part responsible. Alterations in the dopamine system are thought to contribute to behavioral problems.
One 2016 study suggests that cannabis can cause lasting changes to the brains reward system. To measure this, researchers performed brain scans on 59 cannabis consumers who had consumed the herb daily for the past 60 days, or at least 5,000 times in their lives.
The researchers showed the participants images of cannabis and images of other natural products, like their favorite fruit. Brain imaging found that heavy cannabis users were more likely to have a strong pleasure reaction to the cannabis than to the fruit.
The 70 individuals that did not use cannabis had a greater reward response to the fruit. According to study author Dr. Francesca Filbey, this indicates,
Harmful Effects Of Smoking Cannabis: A Cerebrovascular And Neurological Perspective
- 1Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, Amarillo, TX, United States
- 2Center for Blood Brain Barrier Research, Texas Tech University Health Sciences Center, Amarillo, TX, United States
Apart from being used as a medicine, cannabis or marijuana is the most widely abused recreational drug all over the world. The legalization and decriminalization of cannabis in Canada and various states of USA may be the underlying reason of the widespread popularity of it among young population. Various studies have reported about the relationship between cannabis use and different detrimental effects like cardiovascular, cerebrovascular, and neurological complications among different age groups. Specifically, the young population is getting adversely affected by this, harmful yet, readily accessible recreational drug. Although the mechanism behind cannabis mediated neurological and cerebrovascular complications has not been elucidated yet, the results of these studies have confirmed the association of these diseases with cannabis. Given the lack of comprehensive study relating these harmful complications with cannabis use, the aim of this narrative literature review article is to evaluate and summarize current studies on cannabis consumption and cerebrovascular/neurological diseases along with the leading toxicological mechanisms.
How Long Does Marijuana Stay In Your System
While THC side effects wear off after a few hours, the compound itself can hang around in the body for a few weeks after use. How long can it be detected? It depends on the amount/frequency of use as well the type of drug test . Blood tests can detect THC for several hours up to a day after marijuana use. Urine tests can detect it for up to 30 days, while hair tests can reveal THC use for up to 90 days.
Does Marijuana Kill Brain Cells How Weed Affects Cognition
- Does Marijuana Kill Brain Cells? How Weed Affects Cognition
What are the side effects that come to mind when you think of marijuana use? Most likely giggling, slowed speech and movements, and a sudden craving for snacks. This bumbling stereotype might lead you to believe that marijuana makes you dumber, but the scientific consensus seems to be that marijuana does not kill brain cells. This doesnt mean that marijuana is harmless, however.
While weed doesnt directly result in the death of the neurons the way that stress, head trauma, or other types of substances can, it can still go on to cause significantand long-lastingdamage. This brain damage can lead to permanent side effects such as impaired memory, mental illness, and in the case of adolescents and their still-developing brains, a lower IQ.
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