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What Does Weed Do To The Brain

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Synthetic Marijuanas Effect On The Brain

What Does Cannabis Do To The Brain? | Earth Lab

Synthetic Marijuana, a man-made Hallucinogenic substance typically sprayed onto plant material, is not safe for human consumption but has become popular in recent years. Also known as Fake Weed, it produces mind-altering effects and can cause the individual to act in an odd manner. Synthetic Marijuana is illegal and may have toxic ingredients that can cause increased heart rate, unexplained bleeding, and vomiting.

Similarly to Marijuana, Synthetic Marijuana affects the brain by attaching itself to the Cannabinoid receptor type 1 found in both the central and peripheral nervous systems. Synthetic Weed binds more strongly to CB1 receptors than THC, making it at least 100 times more potent in the brain. Because CB1 receptors have multiple locations in the brain, side effects can be intense and harmful.

Synthetic Marijuana may cause the brain and body to experience:

  • Memory loss

What Does Thc Do To The Brain

Cannabis is still illegal under federal law and regarded as a schedule 1 controlled substance. The legal status of marijuana limits the research on how THC affects the brain.

Most of the information regarding the effects of THC is therefore restricted to an individuals experience. So, how does THC affect the brain?

Theres sufficient anecdotal evidence to determine that it does stimulate you mentally. On the other hand, some believe that it may lower your IQ.

Lets have a closer look at how THC affects the brain and what part of the brain THC does affect:

Exploring How Marijuana Alters Brain Function And Its Short

    In part one of what marijuana really does to your brain, we traced the discovery of the cannabinoid receptor. Finding the receptor is the first step in determining how smoking causes a high. The next step is to figure out where cannabinoid receptors are and what theyre doing.

    In 1989, the year after the cannabinoid receptor was discovered, Miles Herkenham led a group of researchers at the National Institute of Mental Health to find out where cannabinoid receptors were located in the brain.

    He first collected brains of three deceased humans whose bodies had been donated to science. He sliced the brains so he could quantify how many cannabinoid receptors were in each region. Then he labeled CP-55,990, the same synthetic version of THC used to discover the cannabinoid receptor, with a radioactive form of hydrogen atom called tritium. He squirted the radio-labeled CP-55,990 onto the brain slices and then took pictures of them using film that was sensitive to tritium. He found the receptor in many parts of the brain, but they were most densely packed in the hippocampus, amygdala, striatum, and cerebellum.

    As we will see, it is not surprising that Herkenham identified these four regionsthey are responsible for many of the functions that marijuana influences.

    1. Impaired memory

    2. Reduced anxiety

    3. Disrupted motor control

    4. Greater appetite

    5. Elevated heart rate

    6. Altered sleep

    7. Reduced pain

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    Healthy Mind Healthy Body

    You can experience beneficial THC effects on your brain and body. Looking after your well-being is important for a happy and healthy life.

    THC is a great alternative to traditional medicine. Once youve eliminated all the potential causes of the short and long-term side effects, youll find THC can help you maintain a healthy mind and body.

    How THC affects your brain and body is in your control, and were happy to assist. If you need advice on which strain of cannabis to choose or which is the highest THC percentage flower, our team at Homegrown Cannabis Co. is available and looks forward to hearing from you.

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    The active chemical in cannabis is called THC. It speeds up thinning of a rats version of the prefrontal cortex. THC binds to docking stations in brain cells. Those docking stations are called CB1 receptors. That CB is short for cannabinoid , meaning these receptors are ideally structured to respond to cannabis compounds known as cannabinoids. These include THC.

    Rats given THC during adolescence lose some brain connections that would otherwise stick around into adulthood. This can alter the rodents behavior and memory. How much depends on the amount of THC and the animals age.

    Researchers cannot study a direct link between THC and prefrontal-cortex thinning in people. But Albaughs colleagues found more CB1 receptors, on average, in the prefrontal cortex of 21 adult men than in other brain regions.

    It is notable that the CB1-rich part in adult brains overlaps with the area that thins faster in cannabis-using teens. The overlap does not prove that cannabis causes the change. It does, however, add to evidence that it may.

    A window of vulnerability

    It is critical to know if teen cannabis use may change how you function as an adult, says Ferland. Until more is known, many researchers recommend postponing any cannabis use until adulthood. They also suggest limiting its frequency and using only low-potency products.

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    How Does Cannabis Use Affect Brain Health Caution Advised More Research Needed

    Statement Highlights:

    • Although recreational and medicinal marijuana is increasingly available across the U.S., public and professional awareness that cannabis use may adversely affect brain health is critical, according to the American Heart Associations first scientific statement on the subject.
    • Animal studies indicate that marijuanas psychoactive component, THC, may lead to behavioral and cognitive abnormalities, particularly if exposure occurs prenatally or during adolescence.
    • However, studies in humans have had mixed results, with some suggesting a higher risk of cognitive impairment due to marijuana use and further research needed on exact consequences.
    • The statement outlines the latest research and the need for future studies to address several open questions about how marijuana may impact brain health.

    Embargoed until 6 a.m. CT / 7 a.m. ET Thursday, Feb 10, 2022

    Theres a lot of uncertainty in the medical community about the health effects of marijuana. This scientific statement is intended to guide health care professionals in having a balanced and intentional discussion with patients about the potential known and unknown effects of marijuana on brain health, said writing group Chair Fernando D. Testai, M.D., Ph.D., FAHA, a professor of neurology and rehabilitation at the University of Illinois at Chicago.

    The statement also highlights numerous open questions on the impact of cannabis on brain health, including:

    Additional Resources:

    Preclinical Studies Related To The Effects Of Cannabinoids And Cannabinoid Receptor On Stroke Outcome

    Different preclinical studies demonstrated the effects of cannabinoids and cannabinoid receptors on stroke outcome, One of particular interest is the fact that cannabinoids not only decreased infarct volume following an ischemic stroke , but also improved early and late functional outcome . Furthermore activation of the endogenous cannabinoid signaling pathway as indirectly demonstrated by a study conducted on CB1 receptor knockout mice which exhibited increased mortality, severe infarct size, and neurological deficits after transient local cerebral ischemia, reduced cerebral blood flow, and increased N-methyl-d-aspartate neurotoxicity when compared to wild type .

    Post-stroke inflammatory responses can be reduced by CB2 ligands whereas, activation of CB1 receptors promotes chemical hypothermia. Both processes result in a reduced stroke infarct volume . Specifically, activation of CB1 receptor activation reduces glutamate release , allied excitotoxicity and increased cerebral blood flow . On the other hand, CB2 receptors activation results in reduced pro-inflammatory cytokines release, neutrophil recruitment and adhesion of leukocyte to cerebral vessels .

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    Your Ability To Drive Becomes Impaired

    Although a study by researchers from the National Highway Traffic Safety Administration concluded that its much safer to drive high than drive drunk, the researchers noted that the reports findings do not indicate that drug use by drivers is risk-free.

    Since THC messes with the areas of the brain associated with coordination and reaction time , NIDA says this also impairs a persons ability to drive while on the drug.

    It May Harm Your Heart

    Is marijuana bad for your brain? – Anees Bahji

    Marijuana makes your heart work harder. Normally the heart beats about 50 to 70 times a minute. But that can jump to 70 to 120 beats or more per minute for 3 hours after the effects of pot kick in. The added strain plus tar and other chemicals in pot may raise your chance of heart attack or stroke. The danger is even bigger if youre older or if you already have heart problems.

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    How Cannabis Interacts With Your Brain

    Cannabis interacts with your brain via the endocannabinoid system . The ECS is primarily responsible for maintaining balance or homeostasis in many of our bodily functions, such as sleep, hunger, pain, inflammation, mood, and memory.

    The ECS contains receptors throughout the body, including the brain, which can be activated by endocannabinoids natural chemicals produced by our bodies but also cannabinoids from the cannabis plant.

    Once absorbed into our bloodstream, these chemicals in cannabis, like THC and CBD, are distributed throughout the body where they can cause some impressive effects.

    When THC or CBD trigger reactions in the brain, they can lead to a wide variety of effects, such as slight changes in coordination, euphoria, or feeling anxious, relaxed, disoriented, confused, or high. Your memory can be impaired, and pain or nausea may be relieved or heightened depending on the dose.

    Exogenous Cannabinoids And Their Receptors

    The principal active component in the complex mixture of cannabinoids present in extracts of the plant Cannabis sativa is 9tetrahydrocannabinol . THC is a sticky resin that is not soluble in water. Smoking remains the most efficient means of delivering the drug and experienced users can titrate the dose by adjusting the frequency and depth of inhalation . THC or cannabis extracts can also be taken orally in fatcontaining foods or dissolved in a suitable pharmaceutical oil, but absorption is delayed and variable . A series of manmade synthetic cannabinoids, some of which are more potent and more water soluble than THC, is also available . All of these compounds act as agonists at the CB1 cannabinoid receptor , which is the only one known to be expressed in the brain. A second cannabinoid receptor, CB2, is expressed only in peripheral tissues, principally in the immune system . THC and the synthetic cannabinoids also act to some extent as agonists at the CB2 receptor. Both cannabinoid receptors are members of the Gprotein coupled class, and their activation is linked to inhibition of adenylate cyclase activity . A series of synthetic drugs is also now available that act as specific antagonists at CB1 or CB2 receptors . One of these compounds, rimonabant, which acts selectively to block CB1 receptors , has been widely used in studies of the actions of cannabinoids in the CNS .

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    It Can Impair Your Ability To Regulate Emotions

    Although many people use marijuana to improve their anxiety and depression, it can actually make these issues worse for some people. ” may induce anxious and depressive symptoms, and it can also increase symptoms of underlying mental health concerns,” says Dr. Chiligiris. “Recent research demonstrates that long-term use can also impair structures that help to regulate difficult emotions.”

    This Post Has 2 Comments

  • Albert Miner 21 Jul 2019Reply

    Point 3 of negative effects: I beg to differ. Ive consumed cannabis for 50 years and every day for the past 10. Im at an age where my doctor orders chest X-rays every couple of years not only to monitor the pot but also checking on my 10 years of tobacco smoking and an unspecified number of years exposed to asbestos. The only time my chest X-rays were dark was during my tobacco decade. In the past 10 years X-rays have shown my lungs clean and pink and my lung capacity has improved.

  • Deneice 21 Jun 2020Reply

    It is unfortunate that people have not found out how to get high on life instead of needing carcinogens to get through life. Playing Russian roulette with once life,especially our youth of today, is a slow suicide. Please people speak truth and be honest about your addiction and get help, you are worth it.

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    Smoking Marijuana And Effects On The Body

    So you took a long draw off a blunt. Now what? The first thing to know is that the effects of smoking pot are a bit different than the effects of eating it.

    When you take in cannabis by inhalation, the kinetics the speed at which effects happen are very fast, Piomelli says. It goes into the lungs, circulates into the heart, and goes up to the brain very quickly. But it also goes away more quickly than if you consume cannabis through other pathways.

    The first thing youll feel is the cardiovascular effect. Blood pressure drops, Piomelli says. That causes an immediate reflex: The heart pumps more blood to restore normal pressure, and with that, heart rate increases. These effects are not pleasant, and they are the main reason why people who first try cannabis dont like it. They feel lightheaded and scared because their heart is beating fast, although those feelings disappear very quickly.

    Next comes the high, as THC travels up to the brain and switches on the CB1 receptors. When you have enough THC in the brain to activate enough endocannabinoid receptors, you get the reason why people use marijuana recreationally: that stoned sensation of euphoria and intoxication that is unique to cannabis, Piomelli says.

    According to Gruber, this process activates the brains reward circuitry, creating a reinforcing effect: You get a shot of dopamine that produces pleasure and makes you feel good.

    The Short Term Effects Of Marijuana Vary

    Although the exact same biological processes occur in everyone who smokes or consumes cannabis, the way those processes make people feel varies wildly.

    Some people are incredibly sensitive to THC while others are less sensitive, Gruber says. Some get very paranoid others have no problem. Some people say oh my god, I got so hungry and ate everything in the house while others dont get hungry at all. If someone hands you a bowl or a vape cartridge of Granddaddy Purple, you will very likely have a different experience than they do, even though youre smoking the same stuff.

    There are many potential reasons for this. So much of it depends on previous use history, whether you have some familiarity with THC and other substances, Gruber says. It also depends on your individual body chemistry and metabolism, as well as the product itself, whether its a cultivar that has high amounts of other cannabinoids that mitigate the effects of THC.

    Another factor is how activated a persons endocannabinoid system is before they use cannabis. Lets say 70 percent of your receptors are activated and only 20 percent of that persons receptors are activated right before they use marijuana, Piomelli says. Because of this difference, you might become panicky after smoking while the other person feels more relaxed. This also explains why the same person can feel different effects on different occasions even if they consume the same product both times.

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    How Does Cannabis Work In The Brain

    When consumers inhale or ingest cannabis, compounds in the herb tap into the endocannabinoid system to produce possible therapeutic effects. Since the ECS regulates such a broad range of bodily functions, cannabis compounds have a very wide range of therapeutic potential.

    As Dr. Ethan Russo, neurologist and medical researcher at Phytecs, explains:

    in the endocannabinoid system one of its main roles in the brain is to regulate neurotransmitter function and again, if theres too much of one kind of neurotransmitter it will bring it down, if theres too little it will bring it up.

    Simply stated, the endocannabinoid system is a large regulatory network that works to create optimum balance in the mind and body. When compounds like THC or the second most popular cannabinoid, cannabidiol , interact with the ECS, they change the balance of the system as a whole.

    Researchers like Russo theorize that a wide variety of conditions are caused by an imbalance or a deficiency of the endocannabinoid system.

    Some symptoms of endocannabinoid deficiency include,

    • Pain
    • Nausea

    Several mood and mental health disorders have also been linked to possible imbalances of the endocannabinoid system. In a 2016 paper, Russo briefly speculates that conditions like PTSD and bipolar disorder may involve the ECS. Physical ailments like fibromyalgia, migraine, and irritable bowel syndrome are also thought to be involved.

    Largest Effect On Young Brains

    Your Brain on Drugs: Marijuana

    Researchers believe that marijuana’s strongest long-term effects occur with young smokers whose brains are still developing neural connections.

    Research into the effects of marijuana on the brain has been hampered by the fact that most people who use marijuana also drink alcohol, or other substances, which can have their own negative effects on the brain.

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    The Effects Of Marijuana On Your Memory

    As you get older, certain aspects of memory normally decline, but that does not mean you are powerless to protect your brain as you age. In fact, there is a lot you can do. In addition to getting regular exercise and eating a Mediterranean style diet, you can also consider what is known and not known about marijuana.

    Is weed bad for your brain?

    Cannabis contains varying amounts of the potentially therapeutic compound cannabidiol , which may help quell anxiety. However, there’s no question that marijuana can produce short-term problems with thinking, working memory, executive function, and psychomotor function . This is because marijuana’s main psychoactive chemical, THC, causes its effect by attaching to receptors in brain regions that are vital for memory formation, including the hippocampus, amygdala, and cerebral cortex. The extent to which long-term use of marijuana produces persistent cognitive problems is not known.

    The laws regarding differ from state to state. Some outlaw it altogether, while others allow it for medical purposesto help relieve pain and nausea, for example. And in a growing number of states, marijuana is legal for recreational use. But it remains illegal at the federal level. For that reason, it has been difficult for researchers in the United States to obtain federal research funding to study marijuana, limiting the amount of high-quality evidence available.

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