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What Occurs In The Brain During The Pruning Process

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Developmental Plasticity: Synaptic Pruning

Synaptic Pruning, Animation

Over the first few years of life, the brain grows rapidly. As eachneuron matures, it sends out multiple branches , increasing thenumber of synaptic contacts and laying the specific connections fromhouse to house, or in the case of the brain, from neuron to neuron. Atbirth, each neuron in the cerebral cortex has approximately 2,500 synapses. By the time an infant is two or threeyears old, the number of synapses is approximately 15,000 synapses perneuron . This amount is about twice that of theaverage adult brain. As we age, old connections are deleted through aprocess called synaptic pruning.

Synaptic pruning eliminates weaker synaptic contacts while strongerconnections are kept and strengthened. Experience determines whichconnections will be strengthened and which will be pruned connectionsthat have been activated most frequently are preserved. Neurons must havea purpose to survive. Without a purpose, neurons die through a processcalled apoptosis in which neurons that do not receive or transmitinformation become damaged and die. Ineffective or weak connections are”pruned” in much the same way a gardener would prune a tree or bush,giving the plant the desired shape. It is plasticity that enables theprocess of developing and pruning connections, allowing the brain to adaptitself to its environment.

What Provokes Parasomnias In Children

Two important processes are operative across childhood. Synaptic pruning first begins at 8 months in the visual cortex and 24 months in the frontal cerebral cortex, removing unnecessary excitatory and inhibitory synaptic connections. Pruning also occurs in the brainstem and cerebellum. The process of pruning is usually complete by age 11, with 40% of synapses in the brain eliminated. During pruning, downregulation of GABAergic projections from the cerebral cortex to the brainstem, or diminished serotoninergic inhibition of the spinal cord, may play a key role in the pathogenesis of sleep/wake transition and NREM arousal parasomnias. During this tender time of pruning, regulation of CPGs may be particularly impaired, permitting the many parasomnias thought to represent an expression of the CPGs.

Genetic predisposition for DoA is the most significant predisposing factor for DoA in children. Psychopathology is usually not a factor in young children with arousal disorders, although in young children with sleepwalking/sleep terrors many will report fears of separation anxiety. Psychopathology is often a significant factor when sleepwalking first appears in older teens and adults, but partial sleep deprivation, situational stress, and genetics often contribute.

Table 1. Central pattern generators that underlie parasomnias and nocturnal frontal lobe epilepsy

Jheel Patel, … Anantha Shekhar, in, 2018

Implication Of Neural Ecm In Psychiatric Disorders

Research into the neurobiological underpinnings of psychiatric disorders points to impaired neurodevelopmental and adult neural plasticity processes, such as cell migration, synaptogenesis, synaptic pruning, and LTP . The growing evidence that the ECM is an important regulator of neuronal adaptation and plasticity suggests that abnormal ECM composition and turnover might underlie development and progression of psychiatric disorders. Specific ECM gene variants, as well as ECM-mediated neural mechanisms induced by environmental factors, might contribute to the pathology of these disorders. In support of this, a strong link between psychiatric disorders and ECM components and remodeling has been established in the last decade.

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In The First Three Years A Childs Brain Has Up To Twice As Many Synapses As It Will Have In Adulthood

Now that were a little more familiar with the fundamentals of the brain, lets take a look at brain development in children. Between conception and age three, a childs brain undergoes an impressive amount of change. At birth, it already has about all of the neurons it will ever have. It doubles in size in the first year, and by age three it has reached 80 percent of its adult volume.8-10

Even more importantly, synapses are formed at a faster rate during these years than at any other time. In fact, the brain creates many more of them than it needs: at age two or three, the brain has up to twice as many synapses as it will have in adulthood . These surplus connections are gradually eliminated throughout childhood and adolescence, a process sometimes referred to as blooming and pruning.11

New Study Reveals How Cannabis Interferes With The Development Of Brain Connections

How much can our brains be altered after we enter ...

Researchers from Osaka University in Japan have discovered that the bodys own cannabinoids known as endocannabinoids play a major role in regulating the formation of brain connections, and that smoking marijuana may interfere with this process. Appearing in the Journal of Neuroscience, this research not only sheds light on some of the potential dangers of regularly using cannabis while the brain is developing, but also helps to clear up the long-standing mystery of how neural circuits are created.

Scientists have known for some time that the young brain undergoes major structural changes before reaching maturity, and that during this formative period, the number and arrangement of connections between neurons known as synapses are extensively remodeled. This neural refurbishment occurs in two stages, the first of which involves the formation and strengthening of new synapses, while the second is characterized by synaptic pruning, whereby any unnecessary connections are erased in order to streamline neural circuits.

To investigate how this process is mediated, the study authors used fluorescent proteins that enabled them to track activity in the brains of newborn mice, focusing particularly on the development of thalamocortical axons , which are the nerve fibers linking the neurons of the thalamus to those of the cortex.

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The Earliest Messages That The Brain Receives Have An Enormous Impact

Early brain development is the foundation of human adaptability and resilience, but these qualities come at a price. Because experiences have such a great potential to affect brain development, children are especially vulnerable to persistent negative influences during this period. On the other hand, these early years are a window of opportunity for parents, caregivers, and communities: positive early experiences have a huge effect on childrens chances for achievement, success, and happiness.

What Are The Most Important Changes In Brain After Birth

Besides synapse formation and pruning, the other most significant event in postnatal brain development is myelination. Newbornsbrains contain very little myelin, the dense impermeable substance that covers the length of mature brain cells and is necessary for clear, efficient electrical transmission.

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How Does Your Brain Prune Its Synapses

Once you reach the age of 2-3 years, you have most of the synapses youll ever have in your brain. Soon after you hit the peak, your brain will begin pruning. During the early years, synaptic pruning is influenced by your genes. Your life experiences then affect the pruning in later life.

A synapse can be strengthened or weakened, depending on how often it is used. You quite literally use it or lose it when it comes to synapses. Those that are often used are strengthened, while less active synapses are weakened until they are finally pruned.

Between the ages of 2 and 10, the pruning is quite harsh about 50% of your synapses are lost during this time. During adolescence, pruning slows down and the number of synapses that you have begins to stabilize. Pruning continues into early adulthood and stops sometime in your 20s. During early adulthood, pruning mainly takes place in the prefrontal cortex, which is associated with personality, critical thinking and decision making.

Synaptic Pruning And Autism

What is Synaptic Pruning | Explained in 2 min

Although there are many factors at play when it comes to autism, glitchy pruning may play a role. Research3 has pointed to the brains of people with autism to be under pruned, compared with a neuro-typical brain. This could actually explain some of the symptoms of autism, such as over-sensitivity to various stimuli. With too many synapses, that all fire at once, a sensory overload will occur.

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Growth In The Hemispheres And Corpus Callosum

Between ages 3 and 6, the left hemisphere of the brain grows dramatically. This side of the brain or hemisphere is typically involved in language skills. The right hemisphere continues to grow throughout early childhood and is involved in tasks that require spatial skills, such as recognizing shapes and patterns. The Corpus Callosum, a dense band of fibers that connects the two hemispheres of the brain, contains approximately 200 million nerve fibers that connect the hemispheres .

The corpus callosum is located a couple of inches below the longitudinal fissure, which runs the length of the brain and separates the two cerebral hemispheres . Because the two hemispheres carry out different functions, they communicate with each other and integrate their activities through the corpus callosum. Additionally, because incoming information is directed toward one hemisphere, such as visual information from the left eye being directed to the right hemisphere, the corpus callosum shares this information with the other hemisphere.

The corpus callosum undergoes a growth spurt between ages 3 and 6, and this results in improved coordination between right and left hemisphere tasks. For example, in comparison to other individuals, children younger than 6 demonstrate difficulty coordinating an Etch A Sketch toy because their corpus callosum is not developed enough to integrate the movements of both hands .

Types Of Cortical Neuroplasticity

Developmental plasticity occurs most profoundly in the first few years of life as neurons grow very rapidly and send out multiple branches, ultimately forming too many connections. In fact, at birth, each neuron in the cerebral cortex has about 2,500 synapses. By the time an infant is two or three years old, the number of synapses is approximately 15,000 per neuron. This amount is about twice that of the average adult brain. The connections that are not reinforced by sensory stimulation eventually weaken, and the connections that are reinforced become stronger. Eventually, efficient pathways of neural connections are carved out. Throughout the life of a human or other mammal, these neural connections are fine-tuned through the organisms interaction with its surroundings. During early childhood, which is known as a critical period of development, the nervous system must receive certain sensory inputs in order to develop properly. Once such a critical period ends, there is a precipitous drop in the number of connections that are maintained, and the ones that do remain are the ones that have been strengthened by the appropriate sensory experiences. This massive pruning back of excess synapses often occurs during adolescence.

American neuroscientist Jordan Grafman has identified four other types of neuroplasticity, known as homologous area adaptation, compensatory masquerade, cross-modal reassignment, and map expansion.

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What Is The Best Way To Develop Baby’s Brain

Here are ideas to encourage brain development:

  • Play. Play is a wonderful way to help a baby or toddler’s brain develop. Play might be a game, talking or singing to actively engage your child’s brain. …
  • Comfort. Babies can feel stress. …
  • Read. Reading is one of the best ways to promote a child’s brain development.
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    Synaptic Pruning And Mental Illness

    Snippets of Science

    Neuroimaging has shown fewer neural connections in the prefrontal brain regions in people diagnosed with mental disorders, such as schizophrenia, than those with neuro-typical brains. Though the research4 is still in its early stages and so the connection is not definite.

    The main mental illness that has been looked at in regards to glitchy pruning is schizophrenia . Research2 suggests that people with schizophrenia have a genetic variant that causes their brain to be a little harsh when pruning, leading to over-pruning.

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    Neuron Tag May Shield Synapses From Brains Pruning Shears

    Nicholette ZeliadtPruning preference:

    Editors Note

    This article was originally published 18 October 2015, based on preliminary data presented at the 2015 Society for Neuroscience annual meeting in Chicago. We have updated the article following publication of the study 10 October 2018 in Neuron1. Updates appear below in brackets.

    A protective molecular tag on neurons can prevent microglia, the brains immune cells, from trimming away their connections with other neurons. The unpublished findings, presented Sunday at the 2015 Society for Neuroscience annual meeting in Chicago, reveal how microglia may target or ignore certain neuronal connections for pruning.

    During development, the brain starts out with more neuronal connections, or synapses, than it needs. Shortly after birth, weak or unused connections are disposed of, and the remaining ones are strengthened. This pruning process is crucial for proper brain wiring and function, and is thought togo awry in autism.

    Microglia, which engulf pathogens, dead cells and other debris in the brain, contribute to synapse pruning during development. A 2012 study showed that these cellular scavengers rely on a certain molecular cue to home in on and gobble up synapses that are weak and unused. Mice that lack this eat me signal, or its receptor, are deficient in pruning and have too many neuronal connections.

    Behavior Of The System For T> 0

    Figure 3. Phase diagrams of the system with respect to and T for four different values of P, in particular for P = 5, 10, 15, and 20, respectively from left to right, and for three values of = 20, 40, 60, respectively from top to bottom . In each panel we show three diagrams: gp, mp, and , as indicated in the label of the color bar. Pink stars in indicate the point of the corresponding time series in Figure 4. Results are for N = 1, 600 and have been averaged over 5 realizations of the system dynamics. In this figure a memory phase appears as a blue region in the diagram of gp and a high value of mp, indicated by a yellow or green color. A SG phase appears as an orange region in gp and a lower value of mp, indicated by a green or blue color, whereas a noisy phase appears as black in gp and dark-blue in mp. Finally, the oscillatory phase appears for high values of gp, and relatively low values of mp . Similarly, homogeneous structures take place for high values of , indicated by a yellow region in the corresponding diagram, whereas heterogeneous structures are for low values of , indicated by a black or dark blue region.

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    Pregnancy Brain: Is It Possible

    The brain during pregnancy reacts to different hormones, mainly oxytocin and prolactin. Amazingly, both cause transformations that remain during the first months after delivery.

    There are even some structures that remain for years. These positive changes allow the mother to get by on less sleep in the first year of her childs life, as well as understand the nonverbal language characteristic of babies.

    In conclusion, the brain during pregnancy is subjected to various changes that guide the woman to a happy motherhood. These alterations are necessary and part of the beauty experienced as a mother.

    Therefore, if you worry about what youll feel like when you have your little one, dont worry: your mind is ready.

    • Maldonado-Durán, M., Sauceda-García, J. M., & Lartigue, T. . Cambios fisiológicos y emocionales durante el embarazo normal y la conducta del feto. Perinatología y Reproducción Humana, 22, 5-14.
    • López, M. E. G., Calva, E. A., Meléndez, J. C., & Bravo, C. S. . Alteraciones psicológicas en la mujer embarazada. Psicología Iberoamericana, 14, 28-35.
    • Oates, M. . 6 Normal emotional changes in pregnancy and the puerperium. Baillières clinical obstetrics and gynaecology, 3, 791-804.

    01 January, 2019

    The Brain In The First Two Years

    Neurons, Synapses and Pruning Oh My!

    Some of the most dramatic physical change that occurs during the first two years of brain development. We are born with most of the brain cells that we will ever have that is, about 85 billion neurons whose function is to store and transmit information . While most of the brains neurons are present at birth, they are not fully mature.

    Figure 3.4.1. Research shows that as early at 4-6 months, infants utilize similar areas of the brain as adults to process information. Image from Deen et al., 2017.

    Communication within the central nervous system , which consists of the brain and spinal cord, begins with nerve cells called neurons. Neurons connect to other neurons via networks of nerve fibers called axons and dendrites. Each neuron typically has a single axon and numerous dendrites that are spread out like branches of a tree . The axon of each neuron reaches toward the dendrites of other neurons at intersections called synapses, which are critical communication links within the brain. Axons and dendrites do not touch, instead, electrical impulses in the axons cause the release of chemicals called neurotransmitters which carry information from the axon of the sending neuron to the dendrites of the receiving neuron.

    Figure 3.4.2. Neuron.

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    Brain’s Synaptic Pruning Continues Into Your 20s

    By Andrew Purcell and Wendy Zukerman

    The synaptic pruning that helps sculpt the adolescent brain into its adult form continues to weed out weak neural connections throughout our 20s. The surprise finding could have implications for our understanding of schizophrenia, a psychological disorder which often appears in early adulthood.

    As children, we overproduce the connections synapses between brain cells. During puberty the body carries out a kind of topiary, snipping away some synapses while allowing others to strengthen. Over a few years, the number of synapses roughly halves, and the adult brain emerges.

    Or so we thought. Pasko Rakic at Yale University and colleagues at the University of Zagreb, Croatia, and the VU University Medical Center in Amsterdam, the Netherlands, have now found that the brains of adults in their 20s are still subject to synaptic pruning.

    Rakics team analysed post-mortem tissue from a brain region called the prefrontal cortex in 32 people aged between 1 week old and 91 years. Specifically, they calculated the density of dendritic spines the tiny projections that protrude from the neurons long dendrites, each of which facilitates communication with other neurons through a synapse.

    Im sure that for many people schizophrenia has a strong developmental component, says Sabine Bahn, who researches schizophrenia at the University of Cambridge although she adds that some cases will likely have a degenerative component.

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